Setting description

TC3 less effective in the HRD+ biomarker signature, TC4 more effective instead

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.13, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 7.6, median = 5.4 mean = 9.9, median = 7.1 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.86, hr = 1.17 af = 1.13, hr = 0.88 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.134, shape = 1.05 scale = 0.096, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 7.3, median = 5.3 mean = 10.2, median = 7.4 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.83, hr = 1.21 af = 1.16, hr = 0.85 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.118, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.3, median = 6 mean = 9.2, median = 6.6 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.95, hr = 1.06 af = 1.04, hr = 0.96 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.132, shape = 1.05 scale = 0.097, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 7.4, median = 5.3 mean = 10.1, median = 7.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.85, hr = 1.19 af = 1.15, hr = 0.87 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.123, shape = 1.05 scale = 0.104, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8, median = 5.8 mean = 9.4, median = 6.8 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.91, hr = 1.1 af = 1.07, hr = 0.93 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 3.12, hr = 0.3 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 8 1 0 12 4
AR- & TP53- 35 23 1 69 10
HRD+ 8 0 0 367 4
TP53+ 3 5 4 5 3
TEfus+ 3 3 0 12 3
PI3K+ 4 6 2 4 7
TC1 TC2 TC3 TC4 TC5
all 0.016 0.002 0.000 0.024 0.008
AR- & TP53- 0.070 0.046 0.002 0.138 0.020
HRD+ 0.016 0.000 0.000 0.734 0.008
TP53+ 0.006 0.010 0.008 0.010 0.006
TEfus+ 0.006 0.006 0.000 0.024 0.006
PI3K+ 0.008 0.012 0.004 0.008 0.014
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 4 2 4 0 6
AR- & TP53- 105 68 168 1 60
HRD+ 18 29 103 0 32
TP53+ 33 38 49 14 34
TEfus+ 20 15 26 1 15
PI3K+ 29 28 32 4 43
TC1 TC2 TC3 TC4 TC5
all 0.008 0.004 0.008 0.000 0.012
AR- & TP53- 0.210 0.136 0.336 0.002 0.120
HRD+ 0.036 0.058 0.206 0.000 0.064
TP53+ 0.066 0.076 0.098 0.028 0.068
TEfus+ 0.040 0.030 0.052 0.002 0.030
PI3K+ 0.058 0.056 0.064 0.008 0.086
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 52 47 21 30 52
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.00 0.000
AR- & TP53- 0.104 0.094 0.042 0.06 0.104
HRD+ 0.000 0.000 0.000 0.00 0.000
TP53+ 0.000 0.000 0.000 0.00 0.000
TEfus+ 0.000 0.000 0.000 0.00 0.000
PI3K+ 0.000 0.000 0.000 0.00 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.316 0.112 0.07 0.012 0.094 0.062
err_type 0.392 0.112 0.07 0.012 0.184 0.062
pow_sign 0.734 0.000 0.00 0.000 0.734 0.000
pow_type 0.828 0.000 0.00 0.000 0.828 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 8 1 0 12 4
all futility 0 4 2 4 0 6
all max_n 0 0 0 0 0 0
all n 368 (334, 409) 168 (103, 223) 172 (110, 227) 144 (99, 204) 154 (110, 212) 168 (109, 223)
all n_unique 337 (305, 376) 154 (94, 209) 157 (101, 211) 132 (90, 190) 142 (99, 194) 153 (97, 207)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 5 (4, 9) 7 (5, 7) 18 (10, 32) 7 (6, 9) 9 (7, 16)
all post_p NA (NA, NA) 0.47 (0.09, 0.87) 0.48 (0.11, 0.88) 0.18 (0.02, 0.6) 1 (0.94, 1) 0.48 (0.1, 0.88)
all rate 0.112 (0.104, 0.12) 0.112 (0.101, 0.127) 0.113 (0.101, 0.126) 0.124 (0.11, 0.143) 0.084 (0.073, 0.094) 0.113 (0.101, 0.127)
AR- & TP53- graduation 0 35 23 1 69 10
AR- & TP53- futility 0 105 68 168 1 60
AR- & TP53- max_n 0 52 47 21 30 52
AR- & TP53- n 219 (191, 253) 91 (30, 150) 92 (33, 147) 75 (30, 128) 82 (36, 133) 92 (41, 150)
AR- & TP53- n_unique 202 (175, 235) 84 (28, 140) 83 (31, 138) 69 (27, 121) 75 (33, 124) 86 (38, 139)
AR- & TP53- time_trial 36 (36, 36) 36 (8, 36) 36 (15, 36) 36 (15, 36) 36 (16, 36) 36 (23, 36)
AR- & TP53- time_stop NA (NA, NA) 10 (6, 26) 15 (8, 27) 19 (12, 32) 13 (9, 21) 18 (10, 31)
AR- & TP53- post_p NA (NA, NA) 0.46 (0.08, 0.87) 0.47 (0.11, 0.87) 0.18 (0.02, 0.67) 1 (0.92, 1) 0.46 (0.09, 0.87)
AR- & TP53- rate 0.111 (0.102, 0.123) 0.113 (0.098, 0.141) 0.112 (0.098, 0.136) 0.128 (0.107, 0.167) 0.075 (0.058, 0.09) 0.113 (0.097, 0.137)
HRD+ graduation 0 8 0 0 367 4
HRD+ futility 0 18 29 103 0 32
HRD+ max_n 0 0 0 0 0 0
HRD+ n 63 (53, 74) 25 (11, 42) 28 (14, 46) 22 (16, 26) 27 (25, 53) 28 (15, 45)
HRD+ n_unique 57 (48, 68) 22 (9, 38) 25 (13, 41) 20 (14, 24) 25 (21, 48) 26 (13, 41)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (31, 36) 23 (16, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 29 (22, 34) 32 (25, 35) 31 (22, 35) 20 (15, 30) 30 (24, 35)
HRD+ post_p NA (NA, NA) 0.41 (0.1, 0.81) 0.45 (0.1, 0.84) 0.01 (0, 0.09) 1 (1, 1) 0.46 (0.11, 0.87)
HRD+ rate 0.113 (0.091, 0.134) 0.118 (0.088, 0.169) 0.114 (0.088, 0.159) 0.221 (0.168, 0.31) 0.035 (0.025, 0.047) 0.112 (0.087, 0.161)
TP53+ graduation 0 3 5 4 5 3
TP53+ futility 0 33 38 49 14 34
TP53+ max_n 0 0 0 0 0 0
TP53+ n 121 (105, 140) 59 (36, 80) 62 (40, 82) 57 (36, 78) 57 (36, 78) 61 (35, 81)
TP53+ n_unique 109 (95, 127) 53 (32, 73) 56 (36, 74) 52 (32, 70) 51 (33, 71) 55 (31, 74)
TP53+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (34, 36) 36 (36, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 22 (14, 30) 18 (14, 30) 24 (16, 32) 19 (16, 28) 20 (12, 32)
TP53+ post_p NA (NA, NA) 0.45 (0.1, 0.87) 0.49 (0.11, 0.87) 0.41 (0.06, 0.8) 0.7 (0.28, 0.95) 0.48 (0.09, 0.88)
TP53+ rate 0.112 (0.097, 0.127) 0.113 (0.096, 0.144) 0.113 (0.095, 0.138) 0.118 (0.099, 0.153) 0.102 (0.085, 0.123) 0.112 (0.095, 0.142)
TEfus+ graduation 0 3 3 0 12 3
TEfus+ futility 0 20 15 26 1 15
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 116 (101, 133) 55 (34, 73) 61 (41, 81) 54 (36, 70) 54 (37, 72) 58 (39, 77)
TEfus+ n_unique 105 (91, 121) 49 (29, 66) 55 (38, 72) 48 (33, 63) 49 (33, 66) 52 (35, 70)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 24 (15, 34) 22 (14, 31) 24 (17, 34) 15 (12, 23) 24 (14, 32)
TEfus+ post_p NA (NA, NA) 0.44 (0.09, 0.88) 0.48 (0.1, 0.86) 0.28 (0.03, 0.7) 0.93 (0.61, 1) 0.46 (0.09, 0.87)
TEfus+ rate 0.111 (0.098, 0.128) 0.114 (0.092, 0.143) 0.112 (0.095, 0.137) 0.125 (0.104, 0.158) 0.084 (0.068, 0.104) 0.114 (0.094, 0.142)
PI3K+ graduation 0 4 6 2 4 7
PI3K+ futility 0 29 28 32 4 43
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 120 (104, 140) 55 (32, 76) 56 (35, 81) 55 (34, 75) 54 (34, 75) 63 (38, 85)
PI3K+ n_unique 109 (94, 126) 50 (28, 70) 50 (31, 74) 50 (31, 69) 49 (31, 69) 57 (34, 78)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
PI3K+ time_stop NA (NA, NA) 23 (14, 34) 22 (16, 35) 22 (16, 32) 22 (19, 32) 15 (9, 26)
PI3K+ post_p NA (NA, NA) 0.44 (0.11, 0.85) 0.46 (0.1, 0.88) 0.34 (0.06, 0.72) 0.81 (0.36, 0.98) 0.47 (0.1, 0.83)
PI3K+ rate 0.112 (0.099, 0.126) 0.115 (0.095, 0.142) 0.113 (0.093, 0.142) 0.122 (0.102, 0.152) 0.096 (0.077, 0.12) 0.115 (0.097, 0.139)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 41 24 1 80 14
—– futility 0 108 70 169 1 65
—– max_n 0 52 47 21 30 52
—– n 124 (99, 150) 45 (19, 101) 46 (14, 95) 37 (10, 92) 34 (10, 88) 42 (11, 92)
—– n_unique 116 (92, 142) 42 (18, 97) 43 (13, 90) 35 (9, 87) 32 (10, 82) 40 (10, 87)
—– post_p NA (NA, NA) 0.48 (0.09, 0.88) 0.43 (0.1, 0.87) 0.43 (0.11, 0.85) 0.44 (0.09, 0.88) 0.44 (0.1, 0.86)
—– rate 0.111 (0.098, 0.128) 0.115 (0.095, 0.153) 0.116 (0.095, 0.162) 0.118 (0.094, 0.183) 0.117 (0.09, 0.184) 0.116 (0.094, 0.188)
—-+ graduation 0 43 29 3 82 21
—-+ futility 0 127 91 183 5 94
—-+ max_n 0 52 47 21 30 52
—-+ n 30 (21, 39) 10 (3, 24) 11 (3, 25) 10 (3, 25) 10 (3, 23) 13 (5, 27)
—-+ n_unique 27 (19, 36) 9 (3, 21) 10 (3, 23) 9 (3, 22) 9 (2, 22) 12 (4, 25)
—-+ post_p NA (NA, NA) 0.44 (0.16, 0.82) 0.44 (0.19, 0.86) 0.45 (0.17, 0.84) 0.48 (0.17, 0.85) 0.45 (0.15, 0.8)
—-+ rate 0.116 (0.088, 0.15) 0.122 (0.084, 0.279) 0.121 (0.082, 0.237) 0.127 (0.082, 0.271) 0.123 (0.076, 0.251) 0.124 (0.088, 0.214)
—+- graduation 0 44 27 1 88 17
—+- futility 0 117 74 183 2 77
—+- max_n 0 52 47 20 30 52
—+- n 5 (2, 9) 2 (0, 6) 3 (1, 6) 2 (0, 5) 2 (0, 6) 2 (0, 5)
—+- n_unique 4 (2, 8) 2 (0, 5) 2 (0, 6) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.48 (0.28, 0.77) 0.47 (0.3, 0.73) 0.46 (0.29, 0.74) 0.49 (0.28, 0.75) 0.51 (0.28, 0.77)
—+- rate 0.126 (0.058, 0.256) 0.134 (0.055, 0.505) 0.131 (0.055, 0.506) 0.145 (0.051, 0.471) 0.128 (0.041, 0.515) 0.129 (0.037, 0.489)
—++ graduation 0 46 32 3 89 23
—++ futility 0 133 94 193 6 101
—++ max_n 0 52 47 20 30 52
—++ n 13 (9, 20) 5 (1, 12) 5 (1, 12) 5 (1, 12) 5 (1, 12) 6 (3, 14)
—++ n_unique 12 (7, 18) 4 (1, 11) 5 (1, 11) 4 (1, 11) 4 (1, 11) 6 (2, 13)
—++ post_p NA (NA, NA) 0.43 (0.22, 0.82) 0.45 (0.21, 0.8) 0.45 (0.22, 0.78) 0.46 (0.22, 0.81) 0.47 (0.19, 0.8)
—++ rate 0.11 (0.075, 0.169) 0.131 (0.072, 0.337) 0.13 (0.069, 0.333) 0.135 (0.073, 0.382) 0.124 (0.065, 0.329) 0.123 (0.071, 0.299)
–+– graduation 0 11 6 4 17 7
–+– futility 0 37 40 51 14 37
–+– max_n 0 0 0 0 0 0
–+– n 25 (18, 33) 13 (5, 24) 11 (4, 24) 10 (4, 22) 10 (4, 21) 11 (3, 21)
–+– n_unique 22 (16, 31) 11 (4, 22) 10 (3, 22) 9 (3, 20) 9 (3, 19) 10 (3, 20)
–+– post_p NA (NA, NA) 0.5 (0.14, 0.86) 0.44 (0.16, 0.86) 0.45 (0.16, 0.85) 0.46 (0.16, 0.85) 0.46 (0.16, 0.84)
–+– rate 0.115 (0.083, 0.154) 0.117 (0.084, 0.233) 0.123 (0.081, 0.289) 0.123 (0.082, 0.277) 0.124 (0.079, 0.241) 0.124 (0.08, 0.294)
–+-+ graduation 0 14 11 5 18 14
–+-+ futility 0 58 59 71 17 66
–+-+ max_n 0 0 0 0 0 0
–+-+ n 24 (18, 32) 10 (4, 22) 9 (3, 21) 9 (3, 21) 10 (3, 21) 11 (5, 23)
–+-+ n_unique 22 (16, 30) 9 (3, 19) 8 (3, 19) 8 (3, 19) 9 (3, 19) 10 (4, 21)
–+-+ post_p NA (NA, NA) 0.46 (0.16, 0.85) 0.47 (0.16, 0.85) 0.45 (0.18, 0.86) 0.49 (0.17, 0.86) 0.48 (0.15, 0.84)
–+-+ rate 0.115 (0.084, 0.159) 0.122 (0.081, 0.278) 0.123 (0.079, 0.271) 0.126 (0.083, 0.249) 0.12 (0.08, 0.268) 0.12 (0.08, 0.247)
–++- graduation 0 14 9 4 27 10
–++- futility 0 54 51 64 14 47
–++- max_n 0 0 0 0 0 0
–++- n 7 (4, 11) 3 (1, 7) 4 (1, 8) 3 (1, 7) 3 (1, 7) 3 (1, 7)
–++- n_unique 6 (3, 10) 3 (1, 7) 4 (1, 7) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.46 (0.25, 0.79) 0.47 (0.24, 0.78) 0.47 (0.25, 0.77) 0.48 (0.26, 0.73) 0.44 (0.27, 0.78)
–++- rate 0.116 (0.059, 0.214) 0.128 (0.052, 0.465) 0.126 (0.061, 0.348) 0.129 (0.055, 0.432) 0.131 (0.055, 0.51) 0.14 (0.056, 0.581)
–+++ graduation 0 17 14 5 28 16
–+++ futility 0 72 69 82 17 74
–+++ max_n 0 0 0 0 0 0
–+++ n 19 (14, 26) 7 (2, 16) 8 (3, 17) 8 (3, 18) 8 (3, 16) 8 (3, 18)
–+++ n_unique 17 (12, 24) 6 (2, 14) 7 (3, 15) 7 (2, 16) 7 (3, 15) 8 (3, 17)
–+++ post_p NA (NA, NA) 0.45 (0.17, 0.8) 0.46 (0.19, 0.84) 0.47 (0.19, 0.83) 0.48 (0.19, 0.83) 0.45 (0.16, 0.85)
–+++ rate 0.11 (0.08, 0.161) 0.128 (0.078, 0.309) 0.122 (0.078, 0.271) 0.12 (0.074, 0.3) 0.123 (0.071, 0.258) 0.126 (0.08, 0.263)
-+— graduation 0 47 24 1 392 18
-+— futility 0 122 91 247 1 92
-+— max_n 0 50 47 19 27 52
-+— n 28 (21, 36) 7 (1, 21) 9 (2, 24) 5 (3, 9) 13 (6, 26) 11 (3, 23)
-+— n_unique 26 (19, 33) 6 (1, 19) 8 (2, 22) 5 (3, 8) 12 (6, 24) 9 (2, 21)
-+— post_p NA (NA, NA) 0.36 (0.14, 0.75) 0.41 (0.15, 0.8) 0.15 (0.05, 0.33) 1 (0.93, 1) 0.43 (0.16, 0.83)
-+— rate 0.113 (0.084, 0.153) 0.134 (0.081, 0.319) 0.124 (0.08, 0.316) 0.238 (0.148, 0.503) 0.035 (0.021, 0.057) 0.117 (0.075, 0.31)
-+–+ graduation 0 48 29 3 390 24
-+–+ futility 0 139 111 258 4 116
-+–+ max_n 0 50 47 19 27 52
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.51) 0.46 (0.46, 0.51) 0.53 (0.53, 0.53) 0.57 (0.47, 0.57)
-+–+ rate 0.103 (0, 0.341) 0.14 (0, 0.688) 0.11 (0, 0.627) 0.233 (0.079, 1.288) 0.049 (0, 0.323) 0.169 (0.015, 1.122)
-+-+- graduation 0 50 27 1 392 21
-+-+- futility 0 130 94 258 2 102
-+-+- max_n 0 50 47 18 27 52
-+-+- n 13 (8, 18) 4 (0, 11) 5 (1, 12) 4 (2, 7) 6 (2, 12) 5 (1, 12)
-+-+- n_unique 12 (7, 17) 4 (0, 10) 4 (1, 11) 3 (2, 6) 5 (2, 11) 5 (1, 11)
-+-+- post_p NA (NA, NA) 0.42 (0.2, 0.76) 0.42 (0.21, 0.8) 0.22 (0.1, 0.39) 0.93 (0.68, 1) 0.44 (0.2, 0.8)
-+-+- rate 0.112 (0.074, 0.177) 0.132 (0.064, 0.332) 0.129 (0.064, 0.418) 0.256 (0.149, 0.601) 0.036 (0.014, 0.075) 0.127 (0.064, 0.336)
-+-++ graduation 0 51 32 3 390 27
-+-++ futility 0 145 113 266 5 122
-+-++ max_n 0 50 47 18 27 52
-+-++ n 5 (2, 9) 2 (0, 5) 3 (0, 6) 2 (1, 5) 2 (0, 5) 2 (0, 5)
-+-++ n_unique 5 (1, 8) 2 (0, 5) 2 (0, 5) 2 (0, 4) 2 (0, 5) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.46 (0.28, 0.69) 0.45 (0.27, 0.69) 0.36 (0.19, 0.5) 0.73 (0.48, 0.92) 0.46 (0.29, 0.7)
-+-++ rate 0.118 (0.054, 0.261) 0.14 (0.048, 0.429) 0.139 (0.048, 0.418) 0.242 (0.119, 0.702) 0.035 (0, 0.145) 0.128 (0.044, 0.489)
-++– graduation 0 18 6 3 370 11
-++– futility 0 51 65 143 10 68
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.56 (0.56, 0.56) 0.53 (0.49, 0.58) 0.45 (0.42, 0.47) 0.52 (0.51, 0.52) 0.55 (0.54, 0.56)
-++– rate 0.17 (0.018, 0.735) 0.171 (0, 0.922) 0.126 (0, 0.886) 0.276 (0, 1.678) 0 (0, 0.18) 0.14 (0, 0.657)
-++-+ graduation 0 20 11 4 369 17
-++-+ futility 0 71 83 158 12 92
-++-+ max_n 0 0 0 0 0 0
-++-+ n 3 (0, 5) 1 (0, 4) 1 (0, 3) 2 (0, 4) 1 (0, 4) 2 (0, 4)
-++-+ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 4)
-++-+ post_p NA (NA, NA) 0.48 (0.33, 0.66) 0.47 (0.35, 0.69) 0.4 (0.26, 0.52) 0.66 (0.5, 0.86) 0.46 (0.34, 0.69)
-++-+ rate 0.138 (0.046, 0.368) 0.14 (0, 0.515) 0.133 (0.029, 0.564) 0.268 (0.114, 1.082) 0.039 (0, 0.151) 0.131 (0.036, 0.614)
-+++- graduation 0 21 9 3 373 14
-+++- futility 0 66 76 151 11 76
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.5 (0.5, 0.5) 0.49 (0.49, 0.49) 0.44 (0.44, 0.44) 0.43 (0.43, 0.44) 0.54 (0.5, 0.58)
-+++- rate 0.154 (0.002, 1.055) 0.081 (0, 0.605) 0.262 (0, 1.714) 0.203 (0.071, 0.596) 0.046 (0, 0.23) 0.179 (0, 1.276)
-++++ graduation 0 23 14 4 372 20
-++++ futility 0 83 93 166 13 99
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 4) 1 (0, 4)
-++++ n_unique 2 (1, 5) 1 (0, 3) 1 (0, 3) 2 (0, 3) 1 (0, 3) 1 (0, 4)
-++++ post_p NA (NA, NA) 0.46 (0.32, 0.67) 0.46 (0.33, 0.63) 0.4 (0.26, 0.52) 0.65 (0.45, 0.88) 0.48 (0.31, 0.65)
-++++ rate 0.126 (0.037, 0.318) 0.133 (0, 0.525) 0.139 (0.027, 0.643) 0.263 (0.107, 0.849) 0.038 (0, 0.146) 0.136 (0, 0.588)
+—- graduation 0 8 1 0 12 4
+—- futility 0 4 2 4 0 6
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 3 (1, 6) 3 (1, 6) 2 (0, 5) 2 (0, 5) 2 (0, 5)
+—- n_unique 4 (1, 7) 2 (1, 5) 3 (1, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
+—- post_p NA (NA, NA) 0.47 (0.3, 0.74) 0.48 (0.28, 0.76) 0.45 (0.3, 0.71) 0.48 (0.3, 0.75) 0.48 (0.31, 0.75)
+—- rate 0.124 (0.058, 0.276) 0.135 (0.049, 0.426) 0.131 (0.053, 0.381) 0.145 (0.047, 0.549) 0.133 (0.041, 0.553) 0.136 (0.046, 0.543)
+—+ graduation 0 12 7 2 15 11
+—+ futility 0 33 30 35 4 45
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 2 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.48 (0.34, 0.66) 0.47 (0.34, 0.64) 0.46 (0.35, 0.65) 0.48 (0.34, 0.69) 0.48 (0.35, 0.68)
+—+ rate 0.122 (0.023, 0.394) 0.129 (0, 0.593) 0.138 (0.032, 0.49) 0.144 (0, 0.605) 0.122 (0, 0.6) 0.126 (0.029, 0.629)
+–+- graduation 0 11 4 0 24 7
+–+- futility 0 24 17 28 1 20
+–+- max_n 0 0 0 0 0 0
+–+- n 8 (4, 12) 4 (1, 8) 4 (2, 9) 3 (1, 7) 3 (1, 7) 3 (1, 7)
+–+- n_unique 7 (4, 11) 3 (1, 7) 4 (2, 8) 3 (1, 6) 3 (1, 7) 3 (1, 7)
+–+- post_p NA (NA, NA) 0.47 (0.25, 0.8) 0.49 (0.26, 0.79) 0.47 (0.27, 0.79) 0.46 (0.25, 0.76) 0.47 (0.25, 0.78)
+–+- rate 0.121 (0.067, 0.22) 0.131 (0.059, 0.393) 0.122 (0.063, 0.273) 0.139 (0.056, 0.454) 0.139 (0.057, 0.445) 0.13 (0.049, 0.467)
+–++ graduation 0 15 10 2 26 13
+–++ futility 0 49 42 51 5 53
+–++ max_n 0 0 0 0 0 0
+–++ n 3 (1, 6) 2 (0, 4) 2 (1, 5) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4)
+–++ post_p NA (NA, NA) 0.48 (0.31, 0.73) 0.48 (0.29, 0.73) 0.48 (0.3, 0.71) 0.44 (0.3, 0.71) 0.48 (0.29, 0.74)
+–++ rate 0.116 (0.044, 0.331) 0.129 (0.037, 0.46) 0.134 (0.05, 0.52) 0.134 (0.043, 0.527) 0.143 (0.045, 0.605) 0.139 (0.049, 0.451)
+-+– graduation 0 11 6 4 17 7
+-+– futility 0 37 40 51 14 37
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.48 (0.35, 0.64) 0.47 (0.38, 0.64) 0.49 (0.38, 0.64) 0.5 (0.37, 0.66) 0.48 (0.38, 0.66)
+-+– rate 0.135 (0, 0.565) 0.154 (0, 0.696) 0.139 (0, 0.89) 0.135 (0, 0.562) 0.129 (0, 0.607) 0.127 (0, 0.688)
+-+-+ graduation 0 14 11 5 18 14
+-+-+ futility 0 58 59 71 17 66
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.56 (0.49, 0.59) 0.48 (0.48, 0.48) 0.48 (0.44, 0.52) 0.5 (0.5, 0.5) 0.47 (0.44, 0.5)
+-+-+ rate 0.184 (0, 1.462) 0.128 (0, 0.36) 0.08 (0, 0.355) 0.14 (0, 1.553) 0.252 (0, 1.653) 0.146 (0, 0.966)
+-++- graduation 0 14 9 4 27 10
+-++- futility 0 54 51 64 14 47
+-++- max_n 0 0 0 0 0 0
+-++- n 21 (15, 28) 7 (3, 17) 11 (5, 21) 8 (3, 18) 8 (3, 17) 8 (3, 18)
+-++- n_unique 19 (13, 26) 7 (3, 16) 9 (4, 19) 7 (3, 17) 7 (3, 15) 7 (2, 16)
+-++- post_p NA (NA, NA) 0.42 (0.17, 0.8) 0.48 (0.18, 0.83) 0.47 (0.18, 0.84) 0.48 (0.17, 0.84) 0.46 (0.2, 0.82)
+-++- rate 0.112 (0.085, 0.156) 0.13 (0.08, 0.296) 0.124 (0.081, 0.221) 0.124 (0.076, 0.299) 0.122 (0.076, 0.313) 0.125 (0.076, 0.303)
+-+++ graduation 0 17 14 5 28 16
+-+++ futility 0 72 69 82 17 74
+-+++ max_n 0 0 0 0 0 0
+-+++ n 15 (10, 22) 6 (2, 14) 7 (3, 15) 6 (2, 15) 7 (2, 15) 7 (3, 15)
+-+++ n_unique 14 (9, 21) 5 (2, 13) 7 (2, 14) 6 (2, 14) 6 (2, 14) 6 (2, 14)
+-+++ post_p NA (NA, NA) 0.44 (0.19, 0.81) 0.47 (0.2, 0.84) 0.44 (0.2, 0.85) 0.46 (0.19, 0.82) 0.45 (0.18, 0.84)
+-+++ rate 0.11 (0.077, 0.167) 0.135 (0.074, 0.3) 0.121 (0.074, 0.284) 0.125 (0.073, 0.313) 0.129 (0.072, 0.343) 0.124 (0.075, 0.312)
++— graduation 0 16 1 0 378 8
++— futility 0 22 31 107 0 38
++— max_n 0 0 0 0 0 0
++— n 9 (5, 14) 4 (1, 8) 4 (1, 8) 3 (2, 6) 5 (1, 9) 4 (1, 8)
++— n_unique 8 (4, 13) 3 (1, 7) 3 (1, 7) 3 (2, 5) 4 (1, 8) 3 (1, 7)
++— post_p NA (NA, NA) 0.42 (0.23, 0.75) 0.46 (0.24, 0.74) 0.25 (0.13, 0.44) 0.88 (0.57, 0.99) 0.44 (0.25, 0.73)
++— rate 0.117 (0.068, 0.191) 0.136 (0.061, 0.374) 0.123 (0.057, 0.364) 0.256 (0.133, 0.576) 0.036 (0.011, 0.094) 0.131 (0.055, 0.38)
++–+ graduation 0 19 7 2 376 14
++–+ futility 0 49 57 132 3 72
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.47 (0.46, 0.49) 0.55 (0.55, 0.55) 0.46 (0.45, 0.47) NA (NA, NA) 0.51 (0.44, 0.54)
++–+ rate 0.086 (0, 1.083) 0.118 (0, 0.427) 0.167 (0, 0.54) 0.591 (0.134, 3.051) 0.068 (0, 0.996) 0.081 (0, 0.279)
++-+- graduation 0 19 4 0 382 11
++-+- futility 0 39 45 126 1 50
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 3) 0 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 1) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.51 (0.4, 0.66) 0.47 (0.39, 0.6) 0.45 (0.34, 0.57) 0.57 (0.44, 0.67) 0.47 (0.4, 0.6)
++-+- rate 0.125 (0, 0.52) 0.125 (0, 0.777) 0.14 (0, 0.977) 0.286 (0.066, 1.239) 0.042 (0, 0.193) 0.131 (0, 0.724)
++-++ graduation 0 22 10 2 380 17
++-++ futility 0 63 68 145 4 79
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.52 (0.52, 0.52) 0.48 (0.46, 0.54) 0.5 (0.45, 0.55) NA (NA, NA) 0.48 (0.45, 0.5)
++-++ rate 0.097 (0, 0.885) 0.133 (0, 0.837) 0.142 (0.028, 1.122) 0.216 (0.075, 0.757) 0.038 (0, 0.073) 0.081 (0, 0.372)
+++– graduation 0 18 6 3 370 11
+++– futility 0 51 65 143 10 68
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.47 (0.42, 0.58) 0.53 (0.44, 0.57) 0.46 (0.42, 0.49) 0.55 (0.46, 0.58) 0.49 (0.43, 0.59)
+++– rate 0.106 (0, 0.575) 0.129 (0, 1.032) 0.1 (0, 0.448) 0.323 (0.11, 1.815) 0.05 (0, 0.234) 0.149 (0, 1.039)
+++-+ graduation 0 20 11 4 369 17
+++-+ futility 0 71 83 158 12 92
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.51 (0.48, 0.54) 0.47 (0.45, 0.51) 0.48 (0.43, 0.5) 0.52 (0.5, 0.55) 0.43 (0.42, 0.48)
+++-+ rate 0.212 (0, 2.372) 0.2 (0, 4.669) 0.077 (0, 0.506) 0.358 (0.079, 0.888) 0.073 (0, 0.276) 0.136 (0, 1.602)
++++- graduation 0 21 9 3 373 14
++++- futility 0 66 76 151 11 76
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.53 (0.52, 0.54)
++++- rate 0.072 (0, 0.527) 0.129 (0, 0.584) 0.162 (0, 2.513) 0.279 (0.106, 0.68) 0 (0, 0.17) 0.131 (0, 0.581)
+++++ graduation 0 23 14 4 372 20
+++++ futility 0 83 93 166 13 99
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) NA (NA, NA) 0.45 (0.41, 0.49) 0.46 (0.46, 0.46) 0.53 (0.48, 0.54) 0.56 (0.51, 0.6)
+++++ rate 0.103 (0, 1.092) 0.097 (0, 0.315) 0.228 (0.075, 1.206) 0.458 (0.1, 3.537) 0.042 (0, 0.675) 0.068 (0, 0.234)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 8 1 12 4
all time_stop 6 (4, 8) 7 (7, 7) 7 (6, 9) 7 (7, 10)
all n_trt 38 (29, 48) 28 (28, 28) 29 (26, 34) 32 (28, 46)
all n_control 57 (44, 78) 79 (79, 79) 65 (58, 88) 69 (61, 91)
all post_p 0.92 (0.87, 0.97) 0.91 (0.91, 0.91) 0.97 (0.93, 0.99) 0.93 (0.89, 0.97)
all order 1 (1, 1) 1 (1, 1) 1 (1, 1.9) 1 (1, 1)
AR- & TP53- count 35 23 1 69 10
AR- & TP53- time_stop 7 (5, 11) 10 (7, 12) 13 (13, 13) 13 (9, 21) 10 (8, 13)
AR- & TP53- n_trt 33 (25, 45) 30 (26, 34) 33 (33, 33) 35 (26, 64) 29 (25, 45)
AR- & TP53- n_control 38 (27, 59) 44 (32, 70) 80 (80, 80) 71 (43, 116) 52 (43, 75)
AR- & TP53- post_p 0.9 (0.85, 0.97) 0.94 (0.89, 0.97) 0.97 (0.97, 0.97) 0.99 (0.93, 1) 0.92 (0.88, 0.98)
AR- & TP53- order 1 (1, 1) 1 (1, 1) 2 (2, 2) 1 (1, 2) 1 (1, 1.1)
HRD+ count 8 367 4
HRD+ time_stop 25 (20, 30) 20 (15, 30) 24 (21, 26)
HRD+ n_trt 26 (25, 32) 26 (25, 41) 26 (26, 28)
HRD+ n_control 40 (26, 58) 30 (19, 49) 30 (28, 34)
HRD+ post_p 0.94 (0.88, 1) 1 (0.99, 1) 0.96 (0.9, 0.99)
HRD+ order 2 (1.7, 3.3) 1 (1, 2) 2 (1.3, 3.4)
TP53+ count 3 5 4 5 3
TP53+ time_stop 14 (10, 14) 14 (13, 16) 15 (12, 18) 16 (15, 18) 13 (12, 14)
TP53+ n_trt 29 (27, 31) 28 (25, 31) 28 (26, 33) 29 (27, 33) 25 (25, 30)
TP53+ n_control 34 (29, 37) 39 (33, 45) 46 (38, 62) 43 (42, 49) 33 (30, 39)
TP53+ post_p 0.96 (0.96, 0.97) 0.96 (0.93, 0.98) 0.98 (0.9, 0.99) 0.99 (0.98, 1) 0.94 (0.9, 0.98)
TP53+ order 1 (1, 1) 1 (1, 2) 1.5 (1, 2.7) 1 (1, 2) 1 (1, 1.8)
TEfus+ count 3 3 12 3
TEfus+ time_stop 14 (13, 18) 13 (12, 19) 14 (12, 20) 15 (14, 17)
TEfus+ n_trt 31 (29, 32) 28 (26, 32) 26 (25, 38) 30 (27, 31)
TEfus+ n_control 41 (39, 53) 39 (38, 51) 40 (28, 67) 40 (31, 46)
TEfus+ post_p 0.94 (0.87, 0.94) 0.95 (0.89, 0.98) 0.98 (0.95, 1) 0.91 (0.88, 0.94)
TEfus+ order 1 (1, 1) 1 (1, 1) 1.5 (1, 2.9) 1 (1, 2.6)
PI3K+ count 4 6 2 4 7
PI3K+ time_stop 16 (14, 20) 17 (14, 22) 16 (14, 18) 19 (18, 22) 11 (9, 13)
PI3K+ n_trt 26 (25, 30) 28 (26, 37) 28 (26, 29) 32 (27, 34) 28 (26, 39)
PI3K+ n_control 46 (37, 59) 50 (38, 66) 54 (46, 62) 54 (46, 73) 27 (20, 39)
PI3K+ post_p 0.94 (0.92, 0.96) 0.97 (0.95, 0.99) 0.94 (0.91, 0.98) 0.99 (0.97, 0.99) 0.97 (0.89, 0.99)
PI3K+ order 2.5 (2, 3) 2 (1, 2) 3 (2.2, 3.8) 3 (2, 4) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 4 2 4 6
all time_stop 4 (4, 9) 6 (5, 7) 18 (10, 32) 11 (8, 18)
all n_trt 30 (26, 45) 29 (27, 31) 72 (33, 97) 43 (25, 64)
all n_control 50 (37, 84) 53 (50, 56) 170 (100, 347) 96 (66, 178)
all post_p 0.05 (0.01, 0.17) 0.11 (0.04, 0.18) 0.02 (0.01, 0.04) 0.03 (0.01, 0.08)
all order 1 (1, 1.7) 1 (1, 1) 2.5 (1, 4) 1 (1, 4.5)
AR- & TP53- count 105 68 168 1 60
AR- & TP53- time_stop 13 (6, 28) 17 (11, 28) 19 (12, 32) 13 (13, 13) 18 (12, 31)
AR- & TP53- n_trt 36 (26, 78) 36 (25, 75) 37 (26, 74) 32 (32, 32) 42 (27, 76)
AR- & TP53- n_control 62 (31, 164) 90 (59, 168) 101 (62, 189) 69 (69, 69) 108 (55, 185)
AR- & TP53- post_p 0.14 (0.03, 0.26) 0.13 (0.03, 0.24) 0.07 (0.01, 0.16) 0.21 (0.21, 0.21) 0.1 (0.02, 0.27)
AR- & TP53- order 1 (1, 2) 1 (1, 3) 1 (1, 3) 1 (1, 1) 1 (1, 2.1)
HRD+ count 18 29 103 32
HRD+ time_stop 30 (26, 34) 32 (25, 35) 31 (22, 35) 31 (24, 35)
HRD+ n_trt 29 (25, 37) 29 (25, 40) 25 (25, 27) 28 (25, 37)
HRD+ n_control 49 (40, 62) 55 (38, 66) 50 (31, 69) 50 (35, 62)
HRD+ post_p 0.15 (0.03, 0.29) 0.15 (0.05, 0.27) 0.01 (0, 0.07) 0.12 (0.03, 0.22)
HRD+ order 3.5 (2, 5) 2 (1, 4) 2 (1, 4) 2 (1, 4.9)
TP53+ count 33 38 49 14 34
TP53+ time_stop 22 (16, 31) 19 (15, 30) 25 (17, 32) 20 (18, 28) 21 (12, 33)
TP53+ n_trt 32 (25, 48) 32 (25, 47) 30 (26, 49) 30 (25, 42) 30 (25, 45)
TP53+ n_control 70 (46, 91) 58 (42, 90) 73 (49, 105) 62 (41, 94) 63 (32, 102)
TP53+ post_p 0.06 (0.01, 0.24) 0.07 (0.01, 0.16) 0.04 (0.01, 0.16) 0.06 (0.01, 0.21) 0.06 (0.01, 0.19)
TP53+ order 2 (1, 3.8) 2 (1, 3) 2 (1, 4) 2 (1, 3.7) 2 (1, 4)
TEfus+ count 20 15 26 1 15
TEfus+ time_stop 26 (19, 34) 25 (16, 31) 24 (17, 34) 33 (33, 33) 27 (16, 33)
TEfus+ n_trt 32 (25, 51) 31 (25, 40) 31 (25, 45) 28 (28, 28) 35 (26, 46)
TEfus+ n_control 76 (48, 107) 75 (40, 98) 71 (45, 124) 108 (108, 108) 72 (42, 105)
TEfus+ post_p 0.04 (0, 0.14) 0.06 (0.01, 0.22) 0.02 (0, 0.08) 0.12 (0.12, 0.12) 0.06 (0.03, 0.17)
TEfus+ order 3 (1, 5.1) 3 (1, 5) 2 (1, 4.5) 3 (3, 3) 3 (1, 4.6)
PI3K+ count 29 28 32 4 43
PI3K+ time_stop 25 (15, 34) 24 (18, 35) 24 (17, 32) 26 (21, 34) 17 (9, 27)
PI3K+ n_trt 30 (25, 44) 30 (26, 45) 32 (26, 44) 40 (28, 52) 31 (25, 41)
PI3K+ n_control 72 (37, 110) 82 (51, 108) 74 (45, 116) 86 (64, 104) 41 (17, 79)
PI3K+ post_p 0.06 (0.02, 0.16) 0.07 (0.01, 0.18) 0.06 (0.01, 0.19) 0.12 (0.1, 0.18) 0.08 (0.01, 0.25)
PI3K+ order 2 (1, 4) 2 (1, 4) 2 (1, 5) 2 (2, 2.7) 2 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
all TC1 time 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8)
all TC1 n 19 (14, 25) 2 (0, 6) 0 (0, 1) 1 (0, 2) 4 (2, 6) 1 (0, 5) 0 (0, 1) 1 (1, 3) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (1, 3) 1 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.59 (0.56, 0.85) 0.56 (0.55, 0.62) NA (NA, NA) 0.54 (0.51, 0.61) 0.57 (0.53, 0.64) 0.56 (0.53, 0.59) 0.52 (0.51, 0.56) 0.57 (0.52, 0.61) 0.55 (0.55, 0.61) NA (NA, NA) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.52, 0.54) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.51, 0.62) 0.55 (0.51, 0.67) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.079 (0.048, 0.101) 0 (0, 0.045) 0 (0, 0) 0 (0, 0.288) 0 (0, 0.086) 0 (0, 0.116) 0 (0, 0) 0 (0, 0.069) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 1.842 (1.842, 1.842) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0.42) 0.208 (0.042, 0.374) NA (NA, NA) NA (NA, NA) 0 (0, 0.031) 0 (0, 0.134) 0 (0, 2.187) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
all TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC2 time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
all TC2 n 8 (8, 8) 3 (3, 3) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 4 (4, 4) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.72 (0.72, 0.72) 0.58 (0.58, 0.58) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.64 (0.64, 0.64) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.116 (0.116, 0.116) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.12 (0.12, 0.12) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.047 (0.047, 0.047) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
all TC4 time 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9)
all TC4 n 5 (3, 10) 1 (0, 4) 0 (0, 0) 1 (0, 2) 2 (0, 6) 2 (1, 6) 0 (0, 1) 1 (0, 2) 4 (3, 6) 0 (0, 0) 2 (0, 4) 1 (0, 1) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0) 2 (0, 4) 2 (1, 3) 2 (1, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.57 (0.55, 0.72) 0.56 (0.53, 0.66) 0.55 (0.55, 0.55) 0.53 (0.51, 0.6) 0.63 (0.58, 0.7) 0.56 (0.52, 0.59) 0.51 (0.5, 0.53) 0.53 (0.52, 0.59) 0.66 (0.53, 0.79) NA (NA, NA) 0.57 (0.54, 0.72) 0.59 (0.52, 0.77) NA (NA, NA) 0.53 (0.51, 0.56) NA (NA, NA) 0.52 (0.52, 0.52) 0.55 (0.52, 0.64) 0.61 (0.61, 0.61) 0.54 (0.52, 0.61) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.56 (0.53, 0.58) 0.56 (0.52, 0.66) 0.58 (0.54, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.06 (0, 0.104) 0 (0, 0.121) 0 (0, 0) 0 (0, 0) 0 (0, 0.102) 0 (0, 0.082) 0.246 (0.045, 0.498) 0 (0, 0.068) 0 (0, 0.079) NA (NA, NA) 0 (0, 0.069) 0 (0, 0.006) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.426) 0 (0, 0.023) 0 (0, 0.047) 0 (0, 0) 0.129 (0, 2.074) NA (NA, NA) 0 (0, 0.109) 0 (0, 0.08) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0.161) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC5 time 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10) 7 (7, 10)
all TC5 n 6 (1, 9) 7 (5, 9) 0 (0, 1) 2 (0, 3) 2 (1, 2) 4 (2, 8) 0 (0, 1) 4 (2, 5) 2 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 3) 0 (0, 1) 0 (0, 0) 2 (0, 3) 3 (1, 4) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.71 (0.69, 0.83) 0.53 (0.52, 0.57) 0.63 (0.63, 0.63) 0.53 (0.52, 0.56) 0.55 (0.53, 0.63) 0.54 (0.54, 0.6) 0.57 (0.57, 0.57) 0.63 (0.6, 0.69) 0.6 (0.53, 0.74) NA (NA, NA) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.55 (0.55, 0.55) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.53 (0.53, 0.54) 0.54 (0.52, 0.57) 0.58 (0.53, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0 (0, 0.039) 0.08 (0.064, 0.096) 0.373 (0.075, 0.671) 0.055 (0.011, 0.118) 0 (0, 0) 0.051 (0, 0.105) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.061 (0.012, 0.109) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.166 (0.033, 0.299) 0 (0, 0) 0.163 (0.163, 0.163) 0.206 (0.098, 0.314) 0 (0, 0) NA (NA, NA) 0 (0, 0.087) 0.109 (0.086, 0.258) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 35 35 35 35 35 35 35 35
AR- & TP53- TC1 time 7 (5, 11) 7 (5, 11) 7 (5, 11) 7 (5, 11) 7 (5, 11) 7 (5, 11) 7 (5, 11) 7 (5, 11)
AR- & TP53- TC1 n 24 (20, 35) 3 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 1)
AR- & TP53- TC1 post_p 0.81 (0.73, 0.91) 0.58 (0.51, 0.71) 0.6 (0.54, 0.62) 0.54 (0.52, 0.64) 0.53 (0.51, 0.59) NA (NA, NA) 0.55 (0.51, 0.63) 0.54 (0.51, 0.56)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.072 (0.055, 0.097) 0.051 (0, 0.108) 0 (0, 0.141) 0 (0, 0.346) 0 (0, 0.083) NA (NA, NA) 0 (0, 0.1) 0 (0, 0.18)
AR- & TP53- TC2 count 23 23 23 23 23 23 23 23
AR- & TP53- TC2 time 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12)
AR- & TP53- TC2 n 21 (18, 26) 3 (1, 5) 0 (0, 1) 1 (0, 4) 2 (0, 6) 0 (0, 0) 1 (0, 2) 0 (0, 1)
AR- & TP53- TC2 post_p 0.85 (0.79, 0.92) 0.57 (0.51, 0.69) 0.55 (0.51, 0.71) 0.6 (0.52, 0.63) 0.61 (0.51, 0.78) NA (NA, NA) 0.56 (0.54, 0.73) 0.54 (0.53, 0.59)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.07 (0.04, 0.094) 0 (0, 0.109) 0.04 (0, 0.63) 0 (0, 0.079) 0 (0, 0.085) 0.077 (0.077, 0.077) 0 (0, 0.035) 0 (0, 0.167)
AR- & TP53- TC3 count 1 1 1 1 1 1 1 1
AR- & TP53- TC3 time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
AR- & TP53- TC3 n 23 (23, 23) 3 (3, 3) 1 (1, 1) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1)
AR- & TP53- TC3 post_p 0.73 (0.73, 0.73) 0.84 (0.84, 0.84) 0.64 (0.64, 0.64) 0.7 (0.7, 0.7) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.087 (0.087, 0.087) 0 (0, 0) 0 (0, 0) 0.085 (0.085, 0.085) 0.091 (0.091, 0.091) NA (NA, NA) NA (NA, NA) 0 (0, 0)
AR- & TP53- TC4 count 69 69 69 69 69 69 69 69
AR- & TP53- TC4 time 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21)
AR- & TP53- TC4 n 18 (11, 36) 4 (1, 14) 0 (0, 2) 2 (0, 4) 7 (4, 13) 0 (0, 0) 3 (1, 6) 1 (0, 3)
AR- & TP53- TC4 post_p 0.78 (0.71, 0.92) 0.64 (0.53, 0.78) 0.57 (0.52, 0.65) 0.56 (0.52, 0.68) 0.83 (0.63, 0.97) NA (NA, NA) 0.67 (0.56, 0.85) 0.6 (0.54, 0.74)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.079 (0.04, 0.101) 0.064 (0, 0.115) 0 (0, 0.385) 0 (0, 0.131) 0.03 (0, 0.058) 0 (0, 0) 0 (0, 0.071) 0 (0, 0.09)
AR- & TP53- TC5 count 10 10 10 10 10 10 10 10
AR- & TP53- TC5 time 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13)
AR- & TP53- TC5 n 16 (13, 26) 6 (3, 13) 0 (0, 2) 3 (1, 5) 2 (1, 5) 0 (0, 0) 0 (0, 2) 0 (0, 2)
AR- & TP53- TC5 post_p 0.79 (0.73, 0.92) 0.69 (0.53, 0.84) 0.57 (0.55, 0.59) 0.57 (0.53, 0.7) 0.58 (0.54, 0.68) NA (NA, NA) 0.53 (0.53, 0.57) 0.55 (0.55, 0.56)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.062 (0.026, 0.103) 0.065 (0.037, 0.119) 0 (0, 0.15) 0.046 (0, 0.144) 0 (0, 0.1) NA (NA, NA) 0 (0, 0.059) 0 (0, 0.316)
HRD+ TC1 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
HRD+ TC1 time 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30) 25 (20, 30)
HRD+ TC1 n 15 (12, 21) 0 (0, 0) 4 (2, 11) 2 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 2) 4 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.84 (0.74, 0.95) NA (NA, NA) 0.73 (0.54, 0.86) 0.63 (0.62, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) 0.66 (0.61, 0.78) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.063 (0.033, 0.121) NA (NA, NA) 0.041 (0, 0.095) 0.036 (0, 0.098) NA (NA, NA) 1.752 (1.752, 1.752) NA (NA, NA) 0.064 (0.017, 0.253) 0.054 (0.036, 0.135) 0.103 (0.103, 0.103) NA (NA, NA) NA (NA, NA) 2.098 (2.098, 2.098) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 367 367 367 367 367 367 367 367 367 367 367 367 367 367 367 367
HRD+ TC4 time 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30) 20 (15, 30)
HRD+ TC4 n 13 (8, 20) 0 (0, 0) 5 (2, 10) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (1, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.96 (0.78, 1) 0.59 (0.59, 0.59) 0.8 (0.59, 0.97) 0.63 (0.52, 0.82) 0.54 (0.54, 0.54) 0.59 (0.52, 0.77) 0.53 (0.53, 0.53) 0.6 (0.52, 0.78) 0.72 (0.55, 0.93) NA (NA, NA) 0.57 (0.51, 0.66) NA (NA, NA) 0.55 (0.52, 0.59) 0.53 (0.53, 0.54) NA (NA, NA) 0.52 (0.5, 0.54)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.032 (0.011, 0.061) 0 (0, 0.267) 0.032 (0, 0.079) 0.024 (0, 0.105) 0 (0, 0.182) 0 (0, 0.127) 0 (0, 0.226) 0 (0, 0.09) 0.029 (0, 0.088) 0.112 (0, 1.093) 0 (0, 0.153) 0 (0, 0.014) 0 (0, 0.294) 0 (0, 0.291) 0 (0, 0.192) 0 (0, 0.66)
HRD+ TC5 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
HRD+ TC5 time 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26) 24 (21, 26)
HRD+ TC5 n 13 (11, 17) 0 (0, 1) 4 (2, 5) 2 (0, 2) 0 (0, 0) 0 (0, 3) 0 (0, 0) 2 (1, 2) 4 (3, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.78 (0.72, 0.9) NA (NA, NA) 0.63 (0.59, 0.67) 0.65 (0.64, 0.67) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.6 (0.54, 0.65) 0.66 (0.53, 0.78) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.07 (0.048, 0.079) 0 (0, 0) 0.026 (0, 0.119) 0 (0, 0.053) NA (NA, NA) 0.411 (0.156, 0.667) NA (NA, NA) 0.173 (0.052, 0.236) 0.086 (0.062, 0.111) NA (NA, NA) 0.041 (0.041, 0.041) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC1 time 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14)
TP53+ TC1 n 9 (8, 10) 5 (4, 5) 2 (0, 4) 7 (3, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 3 (3, 6) 3 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.75 (0.71, 0.84) 0.53 (0.52, 0.64) 0.52 (0.52, 0.53) 0.76 (0.66, 0.77) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.72 (0.7, 0.78) 0.66 (0.55, 0.77) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.049 (0.048, 0.097) 0.105 (0.049, 0.119) 0.033 (0.007, 0.059) 0.037 (0.007, 0.051) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0.026) 0 (0, 0.029) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TP53+ TC2 time 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16)
TP53+ TC2 n 5 (3, 10) 5 (3, 8) 1 (0, 3) 5 (3, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 1 (0, 2) 1 (0, 1) 0 (0, 0) 5 (4, 6) 3 (2, 4) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.6 (0.56, 0.75) 0.69 (0.6, 0.8) 0.55 (0.54, 0.6) 0.64 (0.54, 0.68) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) 0.55 (0.55, 0.56) NA (NA, NA) NA (NA, NA) 0.81 (0.62, 0.83) 0.55 (0.52, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.081 (0.034, 0.092) 0.04 (0, 0.089) 0 (0, 0.015) 0.039 (0.014, 0.129) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.079 (0.016, 0.108) 0 (0, 0.116) NA (NA, NA) 0.049 (0.014, 0.081) 0.11 (0.049, 0.203) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TP53+ TC3 time 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18)
TP53+ TC3 n 6 (4, 7) 4 (3, 5) 2 (0, 4) 5 (4, 8) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 6 (3, 8) 4 (3, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.7 (0.51, 0.89) 0.59 (0.54, 0.72) 0.7 (0.68, 0.73) 0.62 (0.54, 0.71) NA (NA, NA) 0.51 (0.5, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.71 (0.69, 0.79) 0.74 (0.64, 0.79) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.074 (0.043, 0.091) 0.055 (0, 0.112) 0.014 (0.003, 0.025) 0.089 (0.061, 0.113) NA (NA, NA) 0.082 (0.016, 0.133) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.052 (0.014, 0.061) 0.015 (0, 0.037) 0.114 (0.023, 0.206) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TP53+ TC4 time 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18) 16 (15, 18)
TP53+ TC4 n 7 (5, 10) 5 (4, 7) 0 (0, 3) 4 (0, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 4) 0 (0, 0) 7 (2, 9) 4 (1, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.77 (0.71, 0.89) 0.72 (0.59, 0.82) 0.53 (0.51, 0.56) 0.52 (0.5, 0.68) NA (NA, NA) 0.59 (0.59, 0.59) NA (NA, NA) 0.64 (0.62, 0.65) 0.72 (0.72, 0.72) NA (NA, NA) 0.83 (0.72, 0.86) 0.75 (0.63, 0.87) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.059 (0.023, 0.066) 0.053 (0.014, 0.085) 0.043 (0.009, 0.077) 0.13 (0.07, 0.151) NA (NA, NA) 0 (0, 0.043) NA (NA, NA) 0 (0, 0) 0.1 (0.071, 0.13) NA (NA, NA) 0.039 (0.026, 0.053) 0.019 (0, 0.062) 0.597 (0.119, 1.074) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC5 time 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14)
TP53+ TC5 n 4 (2, 8) 5 (5, 7) 2 (0, 2) 8 (7, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 4 (3, 4) 3 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.55 (0.55, 0.73) 0.58 (0.56, 0.72) 0.61 (0.59, 0.63) 0.8 (0.74, 0.89) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.56 (0.54, 0.57) 0.56 (0.52, 0.76) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.026 (0.005, 0.093) 0.101 (0.056, 0.14) 0 (0, 0) 0.054 (0.053, 0.072) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.133 (0.088, 0.146) 0.111 (0.058, 0.113) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC1 time 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18) 14 (13, 18)
TEfus+ TC1 n 3 (1, 3) 1 (0, 3) 2 (2, 3) 5 (3, 5) 3 (1, 4) 1 (1, 3) 0 (0, 0) 1 (0, 2) 2 (0, 4) 2 (0, 4) 5 (1, 8) 5 (4, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.61 (0.61, 0.61) 0.53 (0.53, 0.54) 0.57 (0.52, 0.66) 0.71 (0.67, 0.8) 0.58 (0.54, 0.6) 0.57 (0.56, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.71 (0.62, 0.8) 0.72 (0.71, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.101 (0.02, 0.182) 0.206 (0.198, 0.214) 0.056 (0.011, 0.08) 0.037 (0.007, 0.053) 0.124 (0.025, 0.128) 0 (0, 0.04) NA (NA, NA) 0 (0, 0) 0.204 (0.092, 0.316) 0.106 (0.08, 0.132) 0.108 (0.083, 0.133) 0.06 (0.012, 0.073) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC2 time 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19) 13 (12, 19)
TEfus+ TC2 n 1 (1, 2) 2 (1, 2) 4 (2, 4) 4 (2, 7) 2 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 1) 4 (2, 4) 0 (0, 2) 5 (4, 7) 5 (5, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.52 (0.52, 0.52) 0.54 (0.52, 0.57) 0.54 (0.52, 0.55) 0.6 (0.56, 0.74) 0.66 (0.56, 0.7) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) 0.66 (0.54, 0.78) 0.51 (0.51, 0.51) 0.67 (0.56, 0.78) 0.72 (0.7, 0.9) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.153 (0.031, 0.161) 0 (0, 0.117) 0.082 (0.016, 0.122) 0.046 (0.009, 0.082) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.172 (0.102, 0.201) 0.05 (0.05, 0.05) 0.063 (0.061, 0.074) 0.053 (0.011, 0.061) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
TEfus+ TC4 time 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20)
TEfus+ TC4 n 0 (0, 2) 3 (1, 4) 2 (0, 3) 4 (0, 5) 4 (3, 7) 1 (0, 4) 0 (0, 0) 1 (0, 2) 1 (0, 3) 0 (0, 2) 6 (3, 12) 4 (0, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.58 (0.54, 0.61) 0.59 (0.51, 0.68) 0.56 (0.52, 0.76) 0.57 (0.5, 0.73) 0.71 (0.64, 0.87) 0.62 (0.56, 0.66) NA (NA, NA) 0.6 (0.53, 0.8) 0.62 (0.59, 0.72) 0.52 (0.52, 0.59) 0.76 (0.61, 0.86) 0.68 (0.52, 0.77) 0.59 (0.59, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0.025) 0.063 (0, 0.134) 0.087 (0, 0.194) 0.063 (0, 0.12) 0.017 (0, 0.051) 0 (0, 0.033) 0 (0, 0) 0 (0, 0.023) 0 (0, 0.152) 0 (0, 0.039) 0.051 (0.003, 0.086) 0.038 (0, 0.091) 0.048 (0.01, 0.1) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC5 time 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17) 15 (14, 17)
TEfus+ TC5 n 2 (0, 3) 2 (2, 4) 0 (0, 2) 9 (7, 11) 3 (2, 5) 1 (1, 1) 0 (0, 0) 1 (0, 2) 2 (1, 5) 0 (0, 2) 2 (1, 3) 4 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.6 (0.57, 0.63) 0.52 (0.52, 0.59) 0.52 (0.52, 0.52) 0.75 (0.71, 0.79) 0.58 (0.52, 0.63) 0.53 (0.51, 0.67) NA (NA, NA) NA (NA, NA) 0.71 (0.63, 0.79) NA (NA, NA) 0.53 (0.51, 0.67) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.037 (0.007, 0.066) 0.046 (0.046, 0.12) 0.091 (0.091, 0.091) 0.068 (0.057, 0.093) 0.039 (0.008, 0.088) 0 (0, 0) NA (NA, NA) 0.091 (0.018, 0.163) 0.035 (0.007, 0.078) 0.166 (0.166, 0.166) 0.079 (0.016, 0.106) 0.093 (0.061, 0.125) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
PI3K+ TC1 time 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20) 16 (14, 20)
PI3K+ TC1 n 6 (3, 14) 2 (1, 4) 6 (5, 8) 6 (3, 8) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 2) 1 (0, 1) 0 (0, 1) 2 (0, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.73 (0.61, 0.9) 0.56 (0.53, 0.6) 0.72 (0.68, 0.72) 0.69 (0.61, 0.76) NA (NA, NA) 0.55 (0.55, 0.55) 0.59 (0.59, 0.59) NA (NA, NA) 0.54 (0.54, 0.54) 0.63 (0.63, 0.63) NA (NA, NA) 0.7 (0.56, 0.77) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.074 (0.057, 0.092) 0.086 (0.058, 0.104) 0.053 (0.039, 0.086) 0.066 (0.045, 0.084) NA (NA, NA) 0.058 (0.058, 0.058) 0 (0, 0) 0 (0, 0) 0.083 (0.017, 0.15) 0 (0, 0) 0 (0, 0) 0.043 (0.009, 0.097) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
PI3K+ TC2 time 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22) 17 (14, 22)
PI3K+ TC2 n 6 (2, 10) 4 (1, 4) 5 (4, 8) 4 (3, 5) 0 (0, 0) 1 (0, 2) 1 (0, 2) 0 (0, 1) 1 (0, 2) 2 (0, 2) 0 (0, 0) 7 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.73 (0.55, 0.82) 0.55 (0.51, 0.75) 0.71 (0.63, 0.86) 0.64 (0.62, 0.67) NA (NA, NA) 0.64 (0.59, 0.68) 0.54 (0.51, 0.57) 0.6 (0.59, 0.61) 0.59 (0.59, 0.59) 0.54 (0.53, 0.61) NA (NA, NA) 0.81 (0.68, 0.9) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.081 (0.039, 0.097) 0.1 (0.035, 0.119) 0.062 (0.032, 0.084) 0.072 (0.041, 0.094) NA (NA, NA) 0.032 (0, 0.072) 0 (0, 0.07) 0 (0, 0.529) 0.091 (0.02, 0.136) 0.069 (0.013, 0.107) NA (NA, NA) 0.053 (0.022, 0.072) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC3 time 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18)
PI3K+ TC3 n 8 (5, 12) 2 (2, 3) 6 (5, 7) 4 (3, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.68 (0.58, 0.77) 0.56 (0.56, 0.56) 0.69 (0.59, 0.79) 0.61 (0.58, 0.64) NA (NA, NA) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) 0.55 (0.55, 0.55) NA (NA, NA) 0.73 (0.73, 0.73) NA (NA, NA) 0.68 (0.62, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.094 (0.065, 0.122) 0.069 (0.061, 0.077) 0.072 (0.038, 0.105) 0.027 (0.005, 0.049) NA (NA, NA) 0 (0, 0) 0.082 (0.082, 0.082) 0.124 (0.124, 0.124) 0.128 (0.128, 0.128) 0 (0, 0) NA (NA, NA) 0.015 (0.003, 0.027) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
PI3K+ TC4 time 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22) 19 (18, 22)
PI3K+ TC4 n 10 (6, 11) 0 (0, 3) 6 (4, 10) 2 (0, 5) 0 (0, 0) 3 (1, 4) 1 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 2) 0 (0, 0) 5 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.74 (0.71, 0.8) 0.54 (0.53, 0.55) 0.69 (0.63, 0.91) 0.72 (0.71, 0.73) NA (NA, NA) 0.65 (0.63, 0.71) 0.55 (0.55, 0.56) 0.66 (0.66, 0.66) 0.54 (0.54, 0.54) 0.59 (0.59, 0.59) NA (NA, NA) 0.79 (0.66, 0.86) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.062 (0.037, 0.068) 0.104 (0.076, 0.131) 0.058 (0.037, 0.08) 0.047 (0.044, 0.05) NA (NA, NA) 0.029 (0.006, 0.034) 0.059 (0.012, 0.063) 0 (0, 0) 0 (0, 0.074) 0.133 (0.027, 0.24) NA (NA, NA) 0.06 (0.048, 0.07) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
PI3K+ TC5 time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
PI3K+ TC5 n 8 (6, 12) 3 (1, 5) 5 (4, 8) 5 (2, 8) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 1) 3 (0, 3) 0 (0, 0) 5 (3, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.81 (0.67, 0.9) 0.68 (0.54, 0.79) 0.64 (0.58, 0.72) 0.62 (0.56, 0.81) NA (NA, NA) 0.53 (0.52, 0.54) 0.53 (0.53, 0.53) NA (NA, NA) 0.51 (0.5, 0.52) 0.64 (0.56, 0.73) NA (NA, NA) 0.66 (0.53, 0.76) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.074 (0.047, 0.113) 0.055 (0, 0.089) 0.071 (0, 0.099) 0.048 (0, 0.073) NA (NA, NA) 0 (0, 0) 0.235 (0.047, 0.423) 0.275 (0.275, 0.275) 0 (0, 0) 0.063 (0, 0.142) NA (NA, NA) 0.108 (0.019, 0.132) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC1 time 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9) 4 (4, 9)
all TC1 n 17 (13, 24) 4 (1, 5) 0 (0, 1) 1 (0, 2) 2 (1, 5) 0 (0, 2) 2 (1, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (0, 4) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.21 (0.11, 0.33) 0.44 (0.39, 0.47) NA (NA, NA) 0.47 (0.39, 0.49) 0.45 (0.41, 0.48) 0.48 (0.48, 0.48) 0.37 (0.21, 0.46) 0.4 (0.4, 0.4) 0.39 (0.39, 0.39) NA (NA, NA) 0.38 (0.38, 0.38) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) 0.46 (0.45, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.38 (0.36, 0.39) 0.43 (0.43, 0.43) 0.47 (0.46, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.179 (0.131, 0.212) 0.084 (0.079, 0.304) 6.854 (6.854, 6.854) 0.107 (0.021, 0.228) 0.225 (0.02, 0.864) 0.035 (0.007, 0.063) 0.242 (0.065, 0.316) 1.607 (1.607, 1.607) 1.264 (1.264, 1.264) NA (NA, NA) 0.314 (0.063, 0.566) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.188 (0.149, 0.227) NA (NA, NA) 0.43 (0.086, 0.774) NA (NA, NA) 0.244 (0.049, 0.774) 0.185 (0.185, 0.185) 0.2 (0.04, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC2 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC2 n 10 (8, 12) 0 (0, 0) 0 (0, 1) 0 (0, 1) 3 (1, 5) 0 (0, 1) 1 (0, 2) 0 (0, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 2 (1, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 5 (5, 5) 2 (2, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.28 (0.26, 0.3) NA (NA, NA) 0.41 (0.41, 0.41) 0.46 (0.46, 0.46) 0.44 (0.43, 0.44) 0.39 (0.39, 0.39) NA (NA, NA) 0.5 (0.5, 0.5) 0.46 (0.44, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.41 (0.41, 0.41) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.42 (0.37, 0.46) 0.33 (0.21, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.132 (0.13, 0.135) NA (NA, NA) 0.199 (0.199, 0.199) 0 (0, 0) 0.276 (0.173, 0.378) 0.544 (0.544, 0.544) 0 (0, 0) 0 (0, 0) 1.791 (0.358, 3.224) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 8.289 (8.289, 8.289) 0 (0, 0) 0 (0, 0) 2.071 (0.497, 3.645) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.084 (0.073, 0.095) 0.184 (0.037, 0.332) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC3 time 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32)
all TC3 n 30 (12, 39) 2 (2, 5) 0 (0, 1) 0 (0, 1) 3 (2, 6) 5 (2, 6) 0 (0, 1) 2 (0, 5) 4 (3, 4) 0 (0, 0) 1 (1, 5) 0 (0, 2) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 1) 1 (1, 3) 0 (0, 1) 0 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 1) 5 (1, 9) 4 (0, 8) 3 (2, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.27 (0.21, 0.34) 0.41 (0.16, 0.48) NA (NA, NA) 0.44 (0.44, 0.44) 0.36 (0.23, 0.44) 0.36 (0.14, 0.47) 0.46 (0.46, 0.46) 0.45 (0.44, 0.46) 0.27 (0.27, 0.3) NA (NA, NA) 0.37 (0.23, 0.44) 0.38 (0.38, 0.38) NA (NA, NA) 0.46 (0.45, 0.46) NA (NA, NA) 0.43 (0.43, 0.43) 0.43 (0.37, 0.47) 0.47 (0.47, 0.47) 0.38 (0.33, 0.43) 0.4 (0.4, 0.4) 0.46 (0.46, 0.46) NA (NA, NA) 0.31 (0.17, 0.44) 0.27 (0.22, 0.36) 0.26 (0.26, 0.4) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.13 (0.116, 0.168) 0.178 (0.163, 0.227) 0 (0, 0) 0.283 (0.283, 0.283) 0.159 (0.134, 0.232) 0.179 (0.126, 0.245) 0.315 (0.315, 0.315) 0.198 (0.128, 0.267) 0.288 (0.233, 0.394) NA (NA, NA) 0.19 (0.16, 0.46) 3.341 (0.915, 5.767) NA (NA, NA) 0.21 (0.176, 0.406) NA (NA, NA) 0.156 (0.156, 0.156) 0.153 (0.038, 0.437) 0.065 (0.065, 0.065) 0.323 (0.14, 0.506) 0.151 (0.151, 0.151) 0.427 (0.172, 0.593) 0 (0, 0) 0.147 (0.129, 0.293) 0.183 (0.166, 0.202) 0.277 (0.174, 0.362) NA (NA, NA) 0.581 (0.293, 0.869) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC5 time 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18)
all TC5 n 6 (2, 15) 4 (3, 8) 0 (0, 1) 2 (1, 4) 2 (0, 6) 6 (4, 8) 0 (0, 0) 6 (4, 8) 1 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 2) 2 (0, 2) 0 (0, 0) 0 (0, 0) 2 (0, 4) 3 (1, 6) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.34 (0.11, 0.45) 0.41 (0.29, 0.46) 0.5 (0.5, 0.5) 0.41 (0.34, 0.49) 0.44 (0.33, 0.46) 0.37 (0.26, 0.4) 0.37 (0.37, 0.37) 0.4 (0.26, 0.49) 0.41 (0.35, 0.48) NA (NA, NA) 0.45 (0.44, 0.46) 0.43 (0.39, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) 0.46 (0.46, 0.46) 0.41 (0.39, 0.43) 0.38 (0.33, 0.43) 0.41 (0.41, 0.41) NA (NA, NA) 0.37 (0.34, 0.42) 0.36 (0.24, 0.43) 0.36 (0.36, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.168 (0.128, 0.409) 0.173 (0.118, 0.227) 0.45 (0.09, 0.81) 0.148 (0.096, 0.793) 0.193 (0.14, 0.28) 0.163 (0.122, 0.322) 1.908 (1.908, 1.908) 0.145 (0.052, 0.259) 0.335 (0.04, 4.392) NA (NA, NA) 0.146 (0.095, 0.198) 0.941 (0.407, 1.475) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.34 (0.311, 0.369) 0.049 (0.01, 0.059) 0.31 (0.307, 1.457) 0.241 (0.064, 0.273) 0.135 (0.135, 0.135) NA (NA, NA) 0.33 (0.153, 0.866) 0.223 (0.106, 0.737) 0.101 (0.101, 0.101) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 105 105 105 105 105 105 105 105
AR- & TP53- TC1 time 13 (6, 28) 13 (6, 28) 13 (6, 28) 13 (6, 28) 13 (6, 28) 13 (6, 28) 13 (6, 28) 13 (6, 28)
AR- & TP53- TC1 n 23 (17, 49) 5 (2, 12) 1 (0, 3) 2 (0, 4) 3 (0, 9) 0 (0, 0) 2 (0, 5) 0 (0, 2)
AR- & TP53- TC1 post_p 0.31 (0.1, 0.45) 0.38 (0.17, 0.48) 0.45 (0.31, 0.49) 0.42 (0.27, 0.49) 0.41 (0.21, 0.48) NA (NA, NA) 0.41 (0.24, 0.49) 0.45 (0.39, 0.49)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.128 (0.102, 0.18) 0.164 (0.102, 0.577) 0.221 (0.09, 0.654) 0.204 (0.083, 0.712) 0.17 (0.104, 0.551) 0.232 (0.047, 0.329) 0.194 (0.025, 0.556) 0.152 (0, 0.937)
AR- & TP53- TC2 count 68 68 68 68 68 68 68 68
AR- & TP53- TC2 time 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28)
AR- & TP53- TC2 n 20 (11, 50) 5 (2, 11) 1 (0, 3) 2 (0, 6) 4 (1, 10) 0 (0, 0) 2 (1, 5) 1 (0, 3)
AR- & TP53- TC2 post_p 0.3 (0.13, 0.48) 0.38 (0.25, 0.48) 0.42 (0.32, 0.49) 0.41 (0.25, 0.49) 0.36 (0.17, 0.48) 0.47 (0.47, 0.47) 0.41 (0.28, 0.49) 0.42 (0.33, 0.47)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.13 (0.106, 0.163) 0.173 (0.111, 0.323) 0.203 (0.075, 0.935) 0.203 (0.092, 0.736) 0.175 (0.105, 0.44) 4.614 (1.003, 8.226) 0.186 (0.095, 0.964) 0.222 (0.106, 0.83)
AR- & TP53- TC3 count 168 168 168 168 168 168 168 168
AR- & TP53- TC3 time 19 (12, 32) 19 (12, 32) 19 (12, 32) 19 (12, 32) 19 (12, 32) 19 (12, 32) 19 (12, 32) 19 (12, 32)
AR- & TP53- TC3 n 17 (8, 50) 5 (2, 11) 1 (0, 3) 2 (0, 7) 5 (3, 9) 0 (0, 0) 3 (1, 6) 2 (0, 3)
AR- & TP53- TC3 post_p 0.37 (0.14, 0.48) 0.38 (0.17, 0.47) 0.43 (0.31, 0.49) 0.4 (0.26, 0.48) 0.22 (0.08, 0.39) 0.48 (0.48, 0.48) 0.32 (0.12, 0.44) 0.4 (0.23, 0.47)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.131 (0.104, 0.192) 0.163 (0.11, 0.357) 0.181 (0.079, 0.642) 0.187 (0.11, 0.834) 0.234 (0.136, 0.502) 0.47 (0.039, 1.234) 0.266 (0.136, 0.61) 0.277 (0.133, 0.886)
AR- & TP53- TC4 count 1 1 1 1 1 1 1 1
AR- & TP53- TC4 time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
AR- & TP53- TC4 n 19 (19, 19) 3 (3, 3) 0 (0, 0) 2 (2, 2) 4 (4, 4) 0 (0, 0) 2 (2, 2) 2 (2, 2)
AR- & TP53- TC4 post_p 0.47 (0.47, 0.47) 0.45 (0.45, 0.45) NA (NA, NA) 0.48 (0.48, 0.48) 0.36 (0.36, 0.36) NA (NA, NA) 0.33 (0.33, 0.33) NA (NA, NA)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.119 (0.119, 0.119) 0.148 (0.148, 0.148) NA (NA, NA) 0.129 (0.129, 0.129) 0.202 (0.202, 0.202) NA (NA, NA) 0.636 (0.636, 0.636) 0 (0, 0)
AR- & TP53- TC5 count 60 60 60 60 60 60 60 60
AR- & TP53- TC5 time 18 (12, 31) 18 (12, 31) 18 (12, 31) 18 (12, 31) 18 (12, 31) 18 (12, 31) 18 (12, 31) 18 (12, 31)
AR- & TP53- TC5 n 19 (10, 47) 8 (3, 15) 1 (0, 2) 4 (2, 7) 5 (2, 14) 0 (0, 0) 3 (0, 7) 1 (0, 3)
AR- & TP53- TC5 post_p 0.36 (0.13, 0.45) 0.34 (0.12, 0.47) 0.41 (0.33, 0.5) 0.41 (0.2, 0.49) 0.38 (0.16, 0.48) NA (NA, NA) 0.4 (0.21, 0.49) 0.42 (0.35, 0.47)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.126 (0.102, 0.178) 0.164 (0.114, 0.281) 0.205 (0, 0.789) 0.164 (0.109, 0.41) 0.157 (0.101, 0.524) NA (NA, NA) 0.178 (0.104, 0.538) 0.245 (0.066, 0.757)
HRD+ TC1 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
HRD+ TC1 time 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34) 30 (26, 34)
HRD+ TC1 n 10 (6, 18) 0 (0, 0) 6 (4, 14) 2 (1, 4) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 3) 4 (1, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.29 (0.13, 0.47) NA (NA, NA) 0.33 (0.21, 0.43) 0.4 (0.23, 0.47) NA (NA, NA) 0.38 (0.34, 0.48) NA (NA, NA) 0.39 (0.31, 0.48) 0.39 (0.23, 0.49) NA (NA, NA) 0.43 (0.37, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.161 (0.115, 0.244) 0 (0, 0) 0.15 (0.083, 0.322) 0.256 (0.112, 0.433) NA (NA, NA) 0.291 (0.14, 0.632) NA (NA, NA) 0.272 (0.082, 0.643) 0.158 (0.118, 0.496) 0.143 (0.029, 0.257) 0.1 (0, 0.438) NA (NA, NA) 0.192 (0.086, 0.281) 7.003 (7.003, 7.003) 0.663 (0.663, 0.663) NA (NA, NA)
HRD+ TC2 count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
HRD+ TC2 time 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35) 32 (25, 35)
HRD+ TC2 n 12 (6, 21) 0 (0, 0) 7 (2, 10) 3 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (1, 4) 3 (1, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.4 (0.13, 0.47) NA (NA, NA) 0.36 (0.2, 0.47) 0.4 (0.17, 0.49) NA (NA, NA) 0.42 (0.37, 0.48) NA (NA, NA) 0.45 (0.43, 0.49) 0.37 (0.2, 0.46) NA (NA, NA) 0.42 (0.36, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.36 (0.36, 0.36)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.131 (0.1, 0.192) 4.707 (1.169, 8.244) 0.151 (0.1, 0.328) 0.21 (0.114, 0.391) NA (NA, NA) 0.193 (0.069, 0.743) 0.174 (0.035, 0.313) 0.184 (0.037, 0.624) 0.171 (0.099, 0.637) 0.167 (0.167, 0.167) 0.167 (0.017, 0.872) NA (NA, NA) 0 (0, 0.341) NA (NA, NA) 0.293 (0.186, 0.401) 0.127 (0.127, 0.127)
HRD+ TC3 count 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103
HRD+ TC3 time 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35)
HRD+ TC3 n 8 (5, 12) 0 (0, 0) 5 (3, 9) 3 (1, 5) 0 (0, 0) 2 (0, 4) 0 (0, 0) 2 (0, 4) 4 (2, 7) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.16 (0.07, 0.36) 0.48 (0.47, 0.49) 0.24 (0.12, 0.44) 0.36 (0.21, 0.48) NA (NA, NA) 0.4 (0.28, 0.47) NA (NA, NA) 0.39 (0.27, 0.47) 0.28 (0.11, 0.46) NA (NA, NA) 0.41 (0.35, 0.47) NA (NA, NA) 0.47 (0.43, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.205 (0.145, 0.296) 0.3 (0.065, 0.796) 0.23 (0.143, 0.546) 0.229 (0.129, 0.616) 0.199 (0.139, 0.499) 0.315 (0.136, 0.93) 0.119 (0.086, 0.294) 0.247 (0.139, 0.755) 0.234 (0.123, 0.473) 0.484 (0.109, 2.216) 0.325 (0.109, 1.257) 0.672 (0.634, 0.71) 0.347 (0, 0.769) NA (NA, NA) 0.355 (0.091, 0.812) 0.82 (0.622, 1.018)
HRD+ TC5 count 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32
HRD+ TC5 time 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35)
HRD+ TC5 n 13 (7, 20) 0 (0, 0) 4 (3, 10) 2 (0, 4) 0 (0, 0) 2 (0, 4) 0 (0, 0) 1 (0, 3) 3 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.32 (0.18, 0.47) NA (NA, NA) 0.38 (0.25, 0.48) 0.4 (0.25, 0.47) NA (NA, NA) 0.37 (0.28, 0.48) NA (NA, NA) 0.42 (0.3, 0.49) 0.4 (0.28, 0.47) NA (NA, NA) 0.43 (0.38, 0.48) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.12 (0.102, 0.171) NA (NA, NA) 0.149 (0.101, 0.255) 0.177 (0.112, 0.763) NA (NA, NA) 0.259 (0.128, 0.994) 0.19 (0.093, 0.287) 0.251 (0.098, 0.578) 0.152 (0.108, 0.684) NA (NA, NA) 0.366 (0.107, 1.241) NA (NA, NA) 0.11 (0.022, 0.269) 0.136 (0.136, 0.136) 0.486 (0.486, 0.486) NA (NA, NA)
TP53+ TC1 count 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33
TP53+ TC1 time 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31) 22 (16, 31)
TP53+ TC1 n 7 (4, 15) 6 (3, 13) 2 (0, 4) 5 (2, 8) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 4 (2, 8) 3 (1, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.37 (0.17, 0.48) 0.28 (0.17, 0.46) 0.39 (0.31, 0.45) 0.37 (0.22, 0.49) NA (NA, NA) 0.45 (0.42, 0.49) NA (NA, NA) 0.42 (0.33, 0.44) 0.45 (0.37, 0.48) NA (NA, NA) 0.32 (0.2, 0.46) 0.32 (0.16, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.133 (0.113, 0.264) 0.207 (0.112, 0.348) 0.227 (0.115, 1.672) 0.161 (0.117, 0.373) 0 (0, 0) 0.19 (0, 0.667) 1.315 (1.315, 1.315) 0.261 (0.081, 2.482) 0.123 (0, 3.38) NA (NA, NA) 0.182 (0.11, 0.649) 0.213 (0.112, 0.621) 0.202 (0.038, 0.65) NA (NA, NA) NA (NA, NA) 0.118 (0.118, 0.118)
TP53+ TC2 count 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38
TP53+ TC2 time 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30) 19 (15, 30)
TP53+ TC2 n 5 (3, 10) 4 (2, 9) 3 (1, 5) 5 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 7 (4, 12) 3 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.32 (0.14, 0.47) 0.36 (0.18, 0.46) 0.37 (0.26, 0.46) 0.38 (0.2, 0.48) NA (NA, NA) 0.44 (0.35, 0.48) NA (NA, NA) 0.44 (0.41, 0.47) 0.44 (0.4, 0.48) NA (NA, NA) 0.36 (0.17, 0.49) 0.38 (0.25, 0.48) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.175 (0.116, 0.343) 0.192 (0.11, 0.488) 0.199 (0.117, 0.459) 0.165 (0.112, 0.524) NA (NA, NA) 0.193 (0.062, 0.962) 0 (0, 0) 0.267 (0.116, 0.555) 0.273 (0.114, 1.98) 0 (0, 0) 0.147 (0.103, 0.242) 0.197 (0.106, 0.553) 0.029 (0, 4.837) 0.311 (0.17, 0.452) 0.428 (0.428, 0.428) 0 (0, 0)
TP53+ TC3 count 49 49 49 49 49 49 49 49 49 49 49 49 49 49 49 49
TP53+ TC3 time 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32) 25 (17, 32)
TP53+ TC3 n 7 (3, 15) 5 (2, 11) 2 (0, 4) 4 (2, 7) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 1 (0, 1) 0 (0, 0) 5 (2, 12) 4 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.35 (0.17, 0.49) 0.37 (0.21, 0.48) 0.43 (0.28, 0.49) 0.32 (0.16, 0.47) NA (NA, NA) 0.42 (0.3, 0.47) NA (NA, NA) 0.41 (0.27, 0.47) 0.45 (0.38, 0.48) NA (NA, NA) 0.36 (0.15, 0.47) 0.35 (0.24, 0.46) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.162 (0.107, 0.343) 0.167 (0.114, 0.389) 0.196 (0.091, 0.809) 0.194 (0.122, 0.464) NA (NA, NA) 0.328 (0.121, 0.832) 0.185 (0.135, 0.234) 0.271 (0.142, 0.717) 0.138 (0, 0.464) 0.037 (0.007, 0.066) 0.162 (0.115, 0.341) 0.171 (0.104, 0.317) 0.177 (0, 2.244) 0.803 (0.42, 1.186) 0.505 (0.101, 0.909) NA (NA, NA)
TP53+ TC4 count 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
TP53+ TC4 time 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28) 20 (18, 28)
TP53+ TC4 n 6 (4, 12) 6 (3, 10) 0 (0, 4) 4 (3, 13) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 5 (2, 9) 5 (1, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.32 (0.11, 0.41) 0.39 (0.18, 0.47) 0.43 (0.41, 0.47) 0.34 (0.21, 0.48) NA (NA, NA) 0.49 (0.46, 0.5) NA (NA, NA) 0.5 (0.48, 0.5) 0.47 (0.4, 0.47) NA (NA, NA) 0.34 (0.21, 0.43) 0.39 (0.22, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.174 (0.122, 0.5) 0.153 (0.111, 0.251) 0.19 (0.18, 1.872) 0.159 (0.109, 0.274) 0 (0, 0) 0.24 (0.131, 3.667) NA (NA, NA) 0.019 (0, 0.094) 0.185 (0.076, 0.364) NA (NA, NA) 0.187 (0.128, 0.368) 0.201 (0.118, 1.126) 0.341 (0.158, 0.524) NA (NA, NA) 0.198 (0.198, 0.198) 0 (0, 0)
TP53+ TC5 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
TP53+ TC5 time 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33)
TP53+ TC5 n 5 (2, 8) 8 (4, 11) 2 (0, 4) 5 (2, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 5 (1, 8) 5 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.36 (0.19, 0.48) 0.3 (0.17, 0.49) 0.37 (0.26, 0.45) 0.31 (0.21, 0.47) NA (NA, NA) 0.42 (0.37, 0.45) NA (NA, NA) 0.41 (0.31, 0.48) 0.46 (0.41, 0.48) NA (NA, NA) 0.36 (0.23, 0.48) 0.38 (0.25, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.165 (0.102, 0.47) 0.157 (0.107, 0.235) 0.191 (0.107, 0.687) 0.17 (0.105, 0.367) NA (NA, NA) 0.32 (0.084, 1.261) 0.311 (0.311, 0.311) 0.155 (0.047, 1.891) 0.145 (0.025, 0.341) NA (NA, NA) 0.177 (0.122, 0.631) 0.156 (0.101, 0.376) 0.189 (0.189, 0.189) 0 (0, 0) NA (NA, NA) 0.054 (0.011, 0.096)
TEfus+ TC1 count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
TEfus+ TC1 time 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34) 26 (19, 34)
TEfus+ TC1 n 1 (1, 5) 4 (2, 5) 3 (1, 5) 4 (2, 9) 3 (0, 6) 1 (0, 2) 0 (0, 0) 1 (0, 2) 3 (1, 7) 1 (0, 2) 5 (2, 11) 4 (2, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.38 (0.29, 0.47) 0.34 (0.2, 0.47) 0.39 (0.23, 0.47) 0.39 (0.29, 0.48) 0.36 (0.21, 0.49) 0.41 (0.33, 0.48) NA (NA, NA) 0.43 (0.4, 0.47) 0.4 (0.27, 0.47) 0.38 (0.3, 0.48) 0.37 (0.17, 0.44) 0.34 (0.15, 0.48) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.311 (0.101, 0.963) 0.192 (0.13, 0.389) 0.184 (0.107, 0.62) 0.152 (0.113, 0.438) 0.163 (0.074, 0.351) 0.217 (0.124, 0.346) NA (NA, NA) 0.183 (0.094, 3.785) 0.194 (0.116, 1.053) 0.171 (0.036, 0.972) 0.19 (0.107, 0.571) 0.165 (0.103, 0.562) 0.214 (0.027, 0.589) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
TEfus+ TC2 time 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31) 25 (16, 31)
TEfus+ TC2 n 1 (0, 3) 3 (1, 5) 2 (1, 4) 5 (2, 10) 2 (0, 4) 0 (0, 2) 0 (0, 0) 1 (0, 2) 3 (1, 5) 1 (0, 3) 7 (4, 12) 4 (1, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.44 (0.34, 0.5) 0.28 (0.21, 0.39) 0.42 (0.31, 0.49) 0.36 (0.24, 0.46) 0.45 (0.28, 0.49) 0.37 (0.32, 0.46) NA (NA, NA) 0.42 (0.37, 0.43) 0.43 (0.29, 0.49) 0.42 (0.36, 0.47) 0.34 (0.16, 0.48) 0.4 (0.19, 0.48) 0.46 (0.42, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.19 (0.051, 0.227) 0.223 (0.17, 0.435) 0.141 (0.073, 0.207) 0.171 (0.109, 0.215) 0.128 (0.094, 0.716) 0.442 (0.142, 0.641) NA (NA, NA) 0.147 (0.066, 0.372) 0.152 (0.097, 0.517) 0.232 (0.116, 0.453) 0.142 (0.108, 0.206) 0.171 (0.107, 0.401) 0.25 (0.07, 0.613) NA (NA, NA) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
TEfus+ TC3 time 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34)
TEfus+ TC3 n 2 (0, 3) 3 (0, 9) 1 (0, 3) 4 (1, 7) 4 (2, 7) 2 (0, 3) 0 (0, 0) 1 (0, 3) 1 (0, 3) 1 (0, 4) 6 (2, 10) 4 (2, 8) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.43 (0.33, 0.48) 0.41 (0.28, 0.49) 0.37 (0.26, 0.46) 0.38 (0.27, 0.48) 0.27 (0.16, 0.39) 0.35 (0.23, 0.46) NA (NA, NA) 0.38 (0.33, 0.45) 0.4 (0.27, 0.44) 0.45 (0.27, 0.49) 0.31 (0.14, 0.39) 0.36 (0.23, 0.48) 0.44 (0.39, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.167 (0.06, 0.532) 0.167 (0.109, 0.426) 0.264 (0.124, 1.31) 0.161 (0.116, 0.391) 0.236 (0.149, 0.405) 0.201 (0.108, 1.306) NA (NA, NA) 0.288 (0.106, 0.743) 0.332 (0.133, 2.483) 0.186 (0.08, 0.498) 0.17 (0.13, 0.312) 0.18 (0.123, 0.302) 0.28 (0.152, 1.505) 0.72 (0.72, 0.72) 0.106 (0.021, 0.305) 0.599 (0.599, 0.599)
TEfus+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC4 time 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33)
TEfus+ TC4 n 3 (3, 3) 5 (5, 5) 2 (2, 2) 6 (6, 6) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3) 1 (1, 1) 1 (1, 1) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.45 (0.45, 0.45) 0.48 (0.48, 0.48) 0.43 (0.43, 0.43) 0.25 (0.25, 0.25) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.42 (0.42, 0.42) 0.25 (0.25, 0.25) 0.37 (0.37, 0.37) 0.2 (0.2, 0.2) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.162 (0.162, 0.162) 0.084 (0.084, 0.084) 0.181 (0.181, 0.181) 0.161 (0.161, 0.161) 0.162 (0.162, 0.162) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.168 (0.168, 0.168) 1.072 (1.072, 1.072) 0.389 (0.389, 0.389) 0.258 (0.258, 0.258) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
TEfus+ TC5 time 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33) 27 (16, 33)
TEfus+ TC5 n 1 (0, 2) 4 (2, 7) 1 (0, 5) 5 (2, 13) 4 (1, 7) 1 (0, 5) 0 (0, 0) 0 (0, 2) 2 (1, 5) 2 (1, 3) 5 (2, 10) 4 (2, 7) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.4 (0.32, 0.47) 0.38 (0.22, 0.47) 0.41 (0.3, 0.48) 0.34 (0.17, 0.49) 0.39 (0.18, 0.45) 0.45 (0.4, 0.47) NA (NA, NA) 0.46 (0.41, 0.48) 0.41 (0.25, 0.49) 0.42 (0.27, 0.47) 0.4 (0.16, 0.45) 0.32 (0.12, 0.47) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.289 (0.149, 1.046) 0.162 (0.091, 1.005) 0.192 (0.111, 0.249) 0.154 (0.1, 0.38) 0.158 (0.116, 0.371) 0.138 (0.043, 0.401) NA (NA, NA) 0.143 (0.111, 0.988) 0.206 (0.092, 0.664) 0.213 (0.06, 1.747) 0.21 (0.116, 0.616) 0.178 (0.102, 0.532) 0.34 (0.066, 1.087) NA (NA, NA) 0.131 (0.131, 0.131) NA (NA, NA)
PI3K+ TC1 count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
PI3K+ TC1 time 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34)
PI3K+ TC1 n 7 (3, 18) 3 (1, 6) 6 (2, 10) 4 (2, 9) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 0) 3 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.34 (0.14, 0.46) 0.4 (0.27, 0.48) 0.32 (0.18, 0.45) 0.35 (0.21, 0.47) NA (NA, NA) 0.43 (0.36, 0.48) 0.43 (0.4, 0.49) 0.39 (0.33, 0.46) 0.44 (0.36, 0.48) 0.42 (0.33, 0.44) NA (NA, NA) 0.34 (0.18, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.136 (0.105, 0.274) 0.167 (0.105, 0.32) 0.168 (0.115, 0.506) 0.169 (0.107, 0.278) 0.323 (0.311, 0.335) 0.234 (0.078, 0.566) 0.188 (0.049, 0.269) 0.256 (0.087, 1.031) 0.224 (0.14, 0.902) 0.21 (0.039, 0.632) 0.057 (0.011, 0.103) 0.177 (0.119, 0.635) NA (NA, NA) 0.133 (0.133, 0.133) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28
PI3K+ TC2 time 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35) 24 (18, 35)
PI3K+ TC2 n 6 (3, 11) 4 (1, 8) 4 (1, 11) 6 (2, 11) 0 (0, 0) 1 (0, 2) 1 (0, 3) 1 (0, 3) 1 (0, 3) 2 (1, 3) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
PI3K+ TC2 post_p 0.35 (0.16, 0.49) 0.38 (0.24, 0.46) 0.29 (0.16, 0.46) 0.4 (0.26, 0.48) NA (NA, NA) 0.42 (0.38, 0.49) 0.43 (0.37, 0.47) 0.44 (0.36, 0.47) 0.44 (0.33, 0.47) 0.41 (0.36, 0.48) NA (NA, NA) 0.35 (0.2, 0.47) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.169 (0.108, 0.309) 0.165 (0.113, 0.31) 0.198 (0.127, 0.477) 0.141 (0.104, 0.295) 0 (0, 0) 0.127 (0.072, 0.501) 0.162 (0.082, 0.509) 0.245 (0.125, 0.538) 0.188 (0.087, 0.624) 0.226 (0.09, 0.641) 0.063 (0.013, 0.113) 0.199 (0.107, 0.675) NA (NA, NA) 0.073 (0.073, 0.073) 0.172 (0.072, 0.404) NA (NA, NA)
PI3K+ TC3 count 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32
PI3K+ TC3 time 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32)
PI3K+ TC3 n 6 (2, 11) 3 (1, 8) 5 (3, 11) 4 (2, 7) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 1) 4 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.36 (0.23, 0.48) 0.38 (0.27, 0.48) 0.34 (0.22, 0.47) 0.37 (0.18, 0.48) NA (NA, NA) 0.36 (0.23, 0.4) 0.44 (0.32, 0.48) 0.39 (0.35, 0.47) 0.46 (0.36, 0.48) 0.42 (0.35, 0.46) NA (NA, NA) 0.34 (0.21, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.143 (0.109, 0.351) 0.192 (0.097, 0.995) 0.167 (0.113, 0.31) 0.157 (0.111, 0.504) 0.078 (0.078, 0.078) 0.213 (0.15, 0.642) 0.396 (0.131, 3.066) 0.168 (0.09, 0.641) 0.176 (0, 0.945) 0.235 (0.007, 1.667) 0.037 (0, 0.237) 0.173 (0.111, 0.32) 0.091 (0.091, 0.091) 0.216 (0.216, 0.216) 1.281 (1.281, 1.281) 3.134 (3.134, 3.134)
PI3K+ TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
PI3K+ TC4 time 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34) 26 (21, 34)
PI3K+ TC4 n 10 (6, 15) 3 (2, 5) 10 (4, 14) 6 (4, 7) 0 (0, 0) 0 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 0) 6 (5, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.43 (0.36, 0.48) 0.36 (0.2, 0.48) 0.32 (0.19, 0.46) 0.29 (0.19, 0.39) NA (NA, NA) 0.4 (0.4, 0.4) 0.5 (0.5, 0.5) 0.46 (0.46, 0.46) 0.36 (0.35, 0.45) 0.45 (0.43, 0.47) NA (NA, NA) 0.4 (0.32, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.148 (0.129, 0.167) 0.159 (0.107, 0.265) 0.151 (0.115, 0.322) 0.178 (0.12, 0.473) NA (NA, NA) 0.111 (0.111, 0.111) 0.227 (0.227, 0.227) 0.026 (0.005, 0.117) 0.445 (0.355, 0.839) 1.273 (0.375, 2.171) NA (NA, NA) 0.189 (0.143, 0.2) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43
PI3K+ TC5 time 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27) 17 (9, 27)
PI3K+ TC5 n 7 (5, 15) 4 (1, 6) 6 (4, 10) 4 (2, 7) 0 (0, 0) 0 (0, 3) 0 (0, 2) 0 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 0) 5 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.36 (0.18, 0.46) 0.44 (0.22, 0.49) 0.36 (0.12, 0.48) 0.37 (0.12, 0.46) NA (NA, NA) 0.44 (0.36, 0.49) 0.44 (0.39, 0.47) 0.42 (0.29, 0.48) 0.46 (0.38, 0.46) 0.44 (0.32, 0.47) NA (NA, NA) 0.39 (0.17, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.141 (0.096, 0.248) 0.144 (0.079, 0.475) 0.159 (0.107, 0.288) 0.169 (0.098, 0.34) NA (NA, NA) 0.257 (0.068, 1.202) 0.204 (0.049, 0.607) 0.174 (0.099, 0.485) 0.175 (0, 0.744) 0.205 (0.039, 0.681) 0.216 (0.216, 0.216) 0.156 (0.088, 0.403) NA (NA, NA) 0.194 (0.194, 0.194) 0.32 (0.32, 0.32) NA (NA, NA)