Simulation scenario 8, CR phase

Setting description

TC3 less effective in the HRD+ biomarker signature, TC4 more effective instead

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.13, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 7.6, median = 5.4	mean = 9.9, median = 7.1	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.86, hr = 1.17	af = 1.13, hr = 0.88	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.134, shape = 1.05	scale = 0.096, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 7.3, median = 5.3	mean = 10.2, median = 7.4	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.83, hr = 1.21	af = 1.16, hr = 0.85	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.118, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.3, median = 6	mean = 9.2, median = 6.6	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.95, hr = 1.06	af = 1.04, hr = 0.96	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.132, shape = 1.05	scale = 0.097, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 7.4, median = 5.3	mean = 10.1, median = 7.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.85, hr = 1.19	af = 1.15, hr = 0.87	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.123, shape = 1.05	scale = 0.104, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8, median = 5.8	mean = 9.4, median = 6.8	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.91, hr = 1.1	af = 1.07, hr = 0.93	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 3.12, hr = 0.3	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 8 1 0 12 4 AR- & TP53- 35 23 1 69 10 HRD+ 8 0 0 367 4 TP53+ 3 5 4 5 3 TEfus+ 3 3 0 12 3 PI3K+ 4 6 2 4 7

TC1 TC2 TC3 TC4 TC5 all 0.016 0.002 0.000 0.024 0.008 AR- & TP53- 0.070 0.046 0.002 0.138 0.020 HRD+ 0.016 0.000 0.000 0.734 0.008 TP53+ 0.006 0.010 0.008 0.010 0.006 TEfus+ 0.006 0.006 0.000 0.024 0.006 PI3K+ 0.008 0.012 0.004 0.008 0.014

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 4 2 4 0 6 AR- & TP53- 105 68 168 1 60 HRD+ 18 29 103 0 32 TP53+ 33 38 49 14 34 TEfus+ 20 15 26 1 15 PI3K+ 29 28 32 4 43

TC1 TC2 TC3 TC4 TC5 all 0.008 0.004 0.008 0.000 0.012 AR- & TP53- 0.210 0.136 0.336 0.002 0.120 HRD+ 0.036 0.058 0.206 0.000 0.064 TP53+ 0.066 0.076 0.098 0.028 0.068 TEfus+ 0.040 0.030 0.052 0.002 0.030 PI3K+ 0.058 0.056 0.064 0.008 0.086

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 52 47 21 30 52 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.00 0.000 AR- & TP53- 0.104 0.094 0.042 0.06 0.104 HRD+ 0.000 0.000 0.000 0.00 0.000 TP53+ 0.000 0.000 0.000 0.00 0.000 TEfus+ 0.000 0.000 0.000 0.00 0.000 PI3K+ 0.000 0.000 0.000 0.00 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.316	0.112	0.07	0.012	0.094	0.062
err_type	0.392	0.112	0.07	0.012	0.184	0.062
pow_sign	0.734	0.000	0.00	0.000	0.734	0.000
pow_type	0.828	0.000	0.00	0.000	0.828	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	8	1	0	12	4
all	futility	0	4	2	4	0	6
all	max_n	0	0	0	0	0	0
all	n	368 (334, 409)	168 (103, 223)	172 (110, 227)	144 (99, 204)	154 (110, 212)	168 (109, 223)
all	n_unique	337 (305, 376)	154 (94, 209)	157 (101, 211)	132 (90, 190)	142 (99, 194)	153 (97, 207)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	5 (4, 9)	7 (5, 7)	18 (10, 32)	7 (6, 9)	9 (7, 16)
all	post_p	NA (NA, NA)	0.47 (0.09, 0.87)	0.48 (0.11, 0.88)	0.18 (0.02, 0.6)	1 (0.94, 1)	0.48 (0.1, 0.88)
all	rate	0.112 (0.104, 0.12)	0.112 (0.101, 0.127)	0.113 (0.101, 0.126)	0.124 (0.11, 0.143)	0.084 (0.073, 0.094)	0.113 (0.101, 0.127)
AR- & TP53-	graduation	0	35	23	1	69	10
AR- & TP53-	futility	0	105	68	168	1	60
AR- & TP53-	max_n	0	52	47	21	30	52
AR- & TP53-	n	219 (191, 253)	91 (30, 150)	92 (33, 147)	75 (30, 128)	82 (36, 133)	92 (41, 150)
AR- & TP53-	n_unique	202 (175, 235)	84 (28, 140)	83 (31, 138)	69 (27, 121)	75 (33, 124)	86 (38, 139)
AR- & TP53-	time_trial	36 (36, 36)	36 (8, 36)	36 (15, 36)	36 (15, 36)	36 (16, 36)	36 (23, 36)
AR- & TP53-	time_stop	NA (NA, NA)	10 (6, 26)	15 (8, 27)	19 (12, 32)	13 (9, 21)	18 (10, 31)
AR- & TP53-	post_p	NA (NA, NA)	0.46 (0.08, 0.87)	0.47 (0.11, 0.87)	0.18 (0.02, 0.67)	1 (0.92, 1)	0.46 (0.09, 0.87)
AR- & TP53-	rate	0.111 (0.102, 0.123)	0.113 (0.098, 0.141)	0.112 (0.098, 0.136)	0.128 (0.107, 0.167)	0.075 (0.058, 0.09)	0.113 (0.097, 0.137)
HRD+	graduation	0	8	0	0	367	4
HRD+	futility	0	18	29	103	0	32
HRD+	max_n	0	0	0	0	0	0
HRD+	n	63 (53, 74)	25 (11, 42)	28 (14, 46)	22 (16, 26)	27 (25, 53)	28 (15, 45)
HRD+	n_unique	57 (48, 68)	22 (9, 38)	25 (13, 41)	20 (14, 24)	25 (21, 48)	26 (13, 41)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (31, 36)	23 (16, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	29 (22, 34)	32 (25, 35)	31 (22, 35)	20 (15, 30)	30 (24, 35)
HRD+	post_p	NA (NA, NA)	0.41 (0.1, 0.81)	0.45 (0.1, 0.84)	0.01 (0, 0.09)	1 (1, 1)	0.46 (0.11, 0.87)
HRD+	rate	0.113 (0.091, 0.134)	0.118 (0.088, 0.169)	0.114 (0.088, 0.159)	0.221 (0.168, 0.31)	0.035 (0.025, 0.047)	0.112 (0.087, 0.161)
TP53+	graduation	0	3	5	4	5	3
TP53+	futility	0	33	38	49	14	34
TP53+	max_n	0	0	0	0	0	0
TP53+	n	121 (105, 140)	59 (36, 80)	62 (40, 82)	57 (36, 78)	57 (36, 78)	61 (35, 81)
TP53+	n_unique	109 (95, 127)	53 (32, 73)	56 (36, 74)	52 (32, 70)	51 (33, 71)	55 (31, 74)
TP53+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (34, 36)	36 (36, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	22 (14, 30)	18 (14, 30)	24 (16, 32)	19 (16, 28)	20 (12, 32)
TP53+	post_p	NA (NA, NA)	0.45 (0.1, 0.87)	0.49 (0.11, 0.87)	0.41 (0.06, 0.8)	0.7 (0.28, 0.95)	0.48 (0.09, 0.88)
TP53+	rate	0.112 (0.097, 0.127)	0.113 (0.096, 0.144)	0.113 (0.095, 0.138)	0.118 (0.099, 0.153)	0.102 (0.085, 0.123)	0.112 (0.095, 0.142)
TEfus+	graduation	0	3	3	0	12	3
TEfus+	futility	0	20	15	26	1	15
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	116 (101, 133)	55 (34, 73)	61 (41, 81)	54 (36, 70)	54 (37, 72)	58 (39, 77)
TEfus+	n_unique	105 (91, 121)	49 (29, 66)	55 (38, 72)	48 (33, 63)	49 (33, 66)	52 (35, 70)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	24 (15, 34)	22 (14, 31)	24 (17, 34)	15 (12, 23)	24 (14, 32)
TEfus+	post_p	NA (NA, NA)	0.44 (0.09, 0.88)	0.48 (0.1, 0.86)	0.28 (0.03, 0.7)	0.93 (0.61, 1)	0.46 (0.09, 0.87)
TEfus+	rate	0.111 (0.098, 0.128)	0.114 (0.092, 0.143)	0.112 (0.095, 0.137)	0.125 (0.104, 0.158)	0.084 (0.068, 0.104)	0.114 (0.094, 0.142)
PI3K+	graduation	0	4	6	2	4	7
PI3K+	futility	0	29	28	32	4	43
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	120 (104, 140)	55 (32, 76)	56 (35, 81)	55 (34, 75)	54 (34, 75)	63 (38, 85)
PI3K+	n_unique	109 (94, 126)	50 (28, 70)	50 (31, 74)	50 (31, 69)	49 (31, 69)	57 (34, 78)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
PI3K+	time_stop	NA (NA, NA)	23 (14, 34)	22 (16, 35)	22 (16, 32)	22 (19, 32)	15 (9, 26)
PI3K+	post_p	NA (NA, NA)	0.44 (0.11, 0.85)	0.46 (0.1, 0.88)	0.34 (0.06, 0.72)	0.81 (0.36, 0.98)	0.47 (0.1, 0.83)
PI3K+	rate	0.112 (0.099, 0.126)	0.115 (0.095, 0.142)	0.113 (0.093, 0.142)	0.122 (0.102, 0.152)	0.096 (0.077, 0.12)	0.115 (0.097, 0.139)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	41	24	1	80	14
—–	futility	0	108	70	169	1	65
—–	max_n	0	52	47	21	30	52
—–	n	124 (99, 150)	45 (19, 101)	46 (14, 95)	37 (10, 92)	34 (10, 88)	42 (11, 92)
—–	n_unique	116 (92, 142)	42 (18, 97)	43 (13, 90)	35 (9, 87)	32 (10, 82)	40 (10, 87)
—–	post_p	NA (NA, NA)	0.48 (0.09, 0.88)	0.43 (0.1, 0.87)	0.43 (0.11, 0.85)	0.44 (0.09, 0.88)	0.44 (0.1, 0.86)
—–	rate	0.111 (0.098, 0.128)	0.115 (0.095, 0.153)	0.116 (0.095, 0.162)	0.118 (0.094, 0.183)	0.117 (0.09, 0.184)	0.116 (0.094, 0.188)
—-+	graduation	0	43	29	3	82	21
—-+	futility	0	127	91	183	5	94
—-+	max_n	0	52	47	21	30	52
—-+	n	30 (21, 39)	10 (3, 24)	11 (3, 25)	10 (3, 25)	10 (3, 23)	13 (5, 27)
—-+	n_unique	27 (19, 36)	9 (3, 21)	10 (3, 23)	9 (3, 22)	9 (2, 22)	12 (4, 25)
—-+	post_p	NA (NA, NA)	0.44 (0.16, 0.82)	0.44 (0.19, 0.86)	0.45 (0.17, 0.84)	0.48 (0.17, 0.85)	0.45 (0.15, 0.8)
—-+	rate	0.116 (0.088, 0.15)	0.122 (0.084, 0.279)	0.121 (0.082, 0.237)	0.127 (0.082, 0.271)	0.123 (0.076, 0.251)	0.124 (0.088, 0.214)
—+-	graduation	0	44	27	1	88	17
—+-	futility	0	117	74	183	2	77
—+-	max_n	0	52	47	20	30	52
—+-	n	5 (2, 9)	2 (0, 6)	3 (1, 6)	2 (0, 5)	2 (0, 6)	2 (0, 5)
—+-	n_unique	4 (2, 8)	2 (0, 5)	2 (0, 6)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.48 (0.28, 0.77)	0.47 (0.3, 0.73)	0.46 (0.29, 0.74)	0.49 (0.28, 0.75)	0.51 (0.28, 0.77)
—+-	rate	0.126 (0.058, 0.256)	0.134 (0.055, 0.505)	0.131 (0.055, 0.506)	0.145 (0.051, 0.471)	0.128 (0.041, 0.515)	0.129 (0.037, 0.489)
—++	graduation	0	46	32	3	89	23
—++	futility	0	133	94	193	6	101
—++	max_n	0	52	47	20	30	52
—++	n	13 (9, 20)	5 (1, 12)	5 (1, 12)	5 (1, 12)	5 (1, 12)	6 (3, 14)
—++	n_unique	12 (7, 18)	4 (1, 11)	5 (1, 11)	4 (1, 11)	4 (1, 11)	6 (2, 13)
—++	post_p	NA (NA, NA)	0.43 (0.22, 0.82)	0.45 (0.21, 0.8)	0.45 (0.22, 0.78)	0.46 (0.22, 0.81)	0.47 (0.19, 0.8)
—++	rate	0.11 (0.075, 0.169)	0.131 (0.072, 0.337)	0.13 (0.069, 0.333)	0.135 (0.073, 0.382)	0.124 (0.065, 0.329)	0.123 (0.071, 0.299)
–+–	graduation	0	11	6	4	17	7
–+–	futility	0	37	40	51	14	37
–+–	max_n	0	0	0	0	0	0
–+–	n	25 (18, 33)	13 (5, 24)	11 (4, 24)	10 (4, 22)	10 (4, 21)	11 (3, 21)
–+–	n_unique	22 (16, 31)	11 (4, 22)	10 (3, 22)	9 (3, 20)	9 (3, 19)	10 (3, 20)
–+–	post_p	NA (NA, NA)	0.5 (0.14, 0.86)	0.44 (0.16, 0.86)	0.45 (0.16, 0.85)	0.46 (0.16, 0.85)	0.46 (0.16, 0.84)
–+–	rate	0.115 (0.083, 0.154)	0.117 (0.084, 0.233)	0.123 (0.081, 0.289)	0.123 (0.082, 0.277)	0.124 (0.079, 0.241)	0.124 (0.08, 0.294)
–+-+	graduation	0	14	11	5	18	14
–+-+	futility	0	58	59	71	17	66
–+-+	max_n	0	0	0	0	0	0
–+-+	n	24 (18, 32)	10 (4, 22)	9 (3, 21)	9 (3, 21)	10 (3, 21)	11 (5, 23)
–+-+	n_unique	22 (16, 30)	9 (3, 19)	8 (3, 19)	8 (3, 19)	9 (3, 19)	10 (4, 21)
–+-+	post_p	NA (NA, NA)	0.46 (0.16, 0.85)	0.47 (0.16, 0.85)	0.45 (0.18, 0.86)	0.49 (0.17, 0.86)	0.48 (0.15, 0.84)
–+-+	rate	0.115 (0.084, 0.159)	0.122 (0.081, 0.278)	0.123 (0.079, 0.271)	0.126 (0.083, 0.249)	0.12 (0.08, 0.268)	0.12 (0.08, 0.247)
–++-	graduation	0	14	9	4	27	10
–++-	futility	0	54	51	64	14	47
–++-	max_n	0	0	0	0	0	0
–++-	n	7 (4, 11)	3 (1, 7)	4 (1, 8)	3 (1, 7)	3 (1, 7)	3 (1, 7)
–++-	n_unique	6 (3, 10)	3 (1, 7)	4 (1, 7)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.46 (0.25, 0.79)	0.47 (0.24, 0.78)	0.47 (0.25, 0.77)	0.48 (0.26, 0.73)	0.44 (0.27, 0.78)
–++-	rate	0.116 (0.059, 0.214)	0.128 (0.052, 0.465)	0.126 (0.061, 0.348)	0.129 (0.055, 0.432)	0.131 (0.055, 0.51)	0.14 (0.056, 0.581)
–+++	graduation	0	17	14	5	28	16
–+++	futility	0	72	69	82	17	74
–+++	max_n	0	0	0	0	0	0
–+++	n	19 (14, 26)	7 (2, 16)	8 (3, 17)	8 (3, 18)	8 (3, 16)	8 (3, 18)
–+++	n_unique	17 (12, 24)	6 (2, 14)	7 (3, 15)	7 (2, 16)	7 (3, 15)	8 (3, 17)
–+++	post_p	NA (NA, NA)	0.45 (0.17, 0.8)	0.46 (0.19, 0.84)	0.47 (0.19, 0.83)	0.48 (0.19, 0.83)	0.45 (0.16, 0.85)
–+++	rate	0.11 (0.08, 0.161)	0.128 (0.078, 0.309)	0.122 (0.078, 0.271)	0.12 (0.074, 0.3)	0.123 (0.071, 0.258)	0.126 (0.08, 0.263)
-+—	graduation	0	47	24	1	392	18
-+—	futility	0	122	91	247	1	92
-+—	max_n	0	50	47	19	27	52
-+—	n	28 (21, 36)	7 (1, 21)	9 (2, 24)	5 (3, 9)	13 (6, 26)	11 (3, 23)
-+—	n_unique	26 (19, 33)	6 (1, 19)	8 (2, 22)	5 (3, 8)	12 (6, 24)	9 (2, 21)
-+—	post_p	NA (NA, NA)	0.36 (0.14, 0.75)	0.41 (0.15, 0.8)	0.15 (0.05, 0.33)	1 (0.93, 1)	0.43 (0.16, 0.83)
-+—	rate	0.113 (0.084, 0.153)	0.134 (0.081, 0.319)	0.124 (0.08, 0.316)	0.238 (0.148, 0.503)	0.035 (0.021, 0.057)	0.117 (0.075, 0.31)
-+–+	graduation	0	48	29	3	390	24
-+–+	futility	0	139	111	258	4	116
-+–+	max_n	0	50	47	19	27	52
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.51)	0.46 (0.46, 0.51)	0.53 (0.53, 0.53)	0.57 (0.47, 0.57)
-+–+	rate	0.103 (0, 0.341)	0.14 (0, 0.688)	0.11 (0, 0.627)	0.233 (0.079, 1.288)	0.049 (0, 0.323)	0.169 (0.015, 1.122)
-+-+-	graduation	0	50	27	1	392	21
-+-+-	futility	0	130	94	258	2	102
-+-+-	max_n	0	50	47	18	27	52
-+-+-	n	13 (8, 18)	4 (0, 11)	5 (1, 12)	4 (2, 7)	6 (2, 12)	5 (1, 12)
-+-+-	n_unique	12 (7, 17)	4 (0, 10)	4 (1, 11)	3 (2, 6)	5 (2, 11)	5 (1, 11)
-+-+-	post_p	NA (NA, NA)	0.42 (0.2, 0.76)	0.42 (0.21, 0.8)	0.22 (0.1, 0.39)	0.93 (0.68, 1)	0.44 (0.2, 0.8)
-+-+-	rate	0.112 (0.074, 0.177)	0.132 (0.064, 0.332)	0.129 (0.064, 0.418)	0.256 (0.149, 0.601)	0.036 (0.014, 0.075)	0.127 (0.064, 0.336)
-+-++	graduation	0	51	32	3	390	27
-+-++	futility	0	145	113	266	5	122
-+-++	max_n	0	50	47	18	27	52
-+-++	n	5 (2, 9)	2 (0, 5)	3 (0, 6)	2 (1, 5)	2 (0, 5)	2 (0, 5)
-+-++	n_unique	5 (1, 8)	2 (0, 5)	2 (0, 5)	2 (0, 4)	2 (0, 5)	2 (0, 5)
-+-++	post_p	NA (NA, NA)	0.46 (0.28, 0.69)	0.45 (0.27, 0.69)	0.36 (0.19, 0.5)	0.73 (0.48, 0.92)	0.46 (0.29, 0.7)
-+-++	rate	0.118 (0.054, 0.261)	0.14 (0.048, 0.429)	0.139 (0.048, 0.418)	0.242 (0.119, 0.702)	0.035 (0, 0.145)	0.128 (0.044, 0.489)
-++–	graduation	0	18	6	3	370	11
-++–	futility	0	51	65	143	10	68
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.56 (0.56, 0.56)	0.53 (0.49, 0.58)	0.45 (0.42, 0.47)	0.52 (0.51, 0.52)	0.55 (0.54, 0.56)
-++–	rate	0.17 (0.018, 0.735)	0.171 (0, 0.922)	0.126 (0, 0.886)	0.276 (0, 1.678)	0 (0, 0.18)	0.14 (0, 0.657)
-++-+	graduation	0	20	11	4	369	17
-++-+	futility	0	71	83	158	12	92
-++-+	max_n	0	0	0	0	0	0
-++-+	n	3 (0, 5)	1 (0, 4)	1 (0, 3)	2 (0, 4)	1 (0, 4)	2 (0, 4)
-++-+	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 4)
-++-+	post_p	NA (NA, NA)	0.48 (0.33, 0.66)	0.47 (0.35, 0.69)	0.4 (0.26, 0.52)	0.66 (0.5, 0.86)	0.46 (0.34, 0.69)
-++-+	rate	0.138 (0.046, 0.368)	0.14 (0, 0.515)	0.133 (0.029, 0.564)	0.268 (0.114, 1.082)	0.039 (0, 0.151)	0.131 (0.036, 0.614)
-+++-	graduation	0	21	9	3	373	14
-+++-	futility	0	66	76	151	11	76
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.5 (0.5, 0.5)	0.49 (0.49, 0.49)	0.44 (0.44, 0.44)	0.43 (0.43, 0.44)	0.54 (0.5, 0.58)
-+++-	rate	0.154 (0.002, 1.055)	0.081 (0, 0.605)	0.262 (0, 1.714)	0.203 (0.071, 0.596)	0.046 (0, 0.23)	0.179 (0, 1.276)
-++++	graduation	0	23	14	4	372	20
-++++	futility	0	83	93	166	13	99
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 6)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 4)	1 (0, 4)
-++++	n_unique	2 (1, 5)	1 (0, 3)	1 (0, 3)	2 (0, 3)	1 (0, 3)	1 (0, 4)
-++++	post_p	NA (NA, NA)	0.46 (0.32, 0.67)	0.46 (0.33, 0.63)	0.4 (0.26, 0.52)	0.65 (0.45, 0.88)	0.48 (0.31, 0.65)
-++++	rate	0.126 (0.037, 0.318)	0.133 (0, 0.525)	0.139 (0.027, 0.643)	0.263 (0.107, 0.849)	0.038 (0, 0.146)	0.136 (0, 0.588)
+—-	graduation	0	8	1	0	12	4
+—-	futility	0	4	2	4	0	6
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	3 (1, 6)	3 (1, 6)	2 (0, 5)	2 (0, 5)	2 (0, 5)
+—-	n_unique	4 (1, 7)	2 (1, 5)	3 (1, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
+—-	post_p	NA (NA, NA)	0.47 (0.3, 0.74)	0.48 (0.28, 0.76)	0.45 (0.3, 0.71)	0.48 (0.3, 0.75)	0.48 (0.31, 0.75)
+—-	rate	0.124 (0.058, 0.276)	0.135 (0.049, 0.426)	0.131 (0.053, 0.381)	0.145 (0.047, 0.549)	0.133 (0.041, 0.553)	0.136 (0.046, 0.543)
+—+	graduation	0	12	7	2	15	11
+—+	futility	0	33	30	35	4	45
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	2 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.48 (0.34, 0.66)	0.47 (0.34, 0.64)	0.46 (0.35, 0.65)	0.48 (0.34, 0.69)	0.48 (0.35, 0.68)
+—+	rate	0.122 (0.023, 0.394)	0.129 (0, 0.593)	0.138 (0.032, 0.49)	0.144 (0, 0.605)	0.122 (0, 0.6)	0.126 (0.029, 0.629)
+–+-	graduation	0	11	4	0	24	7
+–+-	futility	0	24	17	28	1	20
+–+-	max_n	0	0	0	0	0	0
+–+-	n	8 (4, 12)	4 (1, 8)	4 (2, 9)	3 (1, 7)	3 (1, 7)	3 (1, 7)
+–+-	n_unique	7 (4, 11)	3 (1, 7)	4 (2, 8)	3 (1, 6)	3 (1, 7)	3 (1, 7)
+–+-	post_p	NA (NA, NA)	0.47 (0.25, 0.8)	0.49 (0.26, 0.79)	0.47 (0.27, 0.79)	0.46 (0.25, 0.76)	0.47 (0.25, 0.78)
+–+-	rate	0.121 (0.067, 0.22)	0.131 (0.059, 0.393)	0.122 (0.063, 0.273)	0.139 (0.056, 0.454)	0.139 (0.057, 0.445)	0.13 (0.049, 0.467)
+–++	graduation	0	15	10	2	26	13
+–++	futility	0	49	42	51	5	53
+–++	max_n	0	0	0	0	0	0
+–++	n	3 (1, 6)	2 (0, 4)	2 (1, 5)	2 (0, 4)	2 (0, 4)	2 (0, 5)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)
+–++	post_p	NA (NA, NA)	0.48 (0.31, 0.73)	0.48 (0.29, 0.73)	0.48 (0.3, 0.71)	0.44 (0.3, 0.71)	0.48 (0.29, 0.74)
+–++	rate	0.116 (0.044, 0.331)	0.129 (0.037, 0.46)	0.134 (0.05, 0.52)	0.134 (0.043, 0.527)	0.143 (0.045, 0.605)	0.139 (0.049, 0.451)
+-+–	graduation	0	11	6	4	17	7
+-+–	futility	0	37	40	51	14	37
+-+–	max_n	0	0	0	0	0	0
+-+–	n	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.48 (0.35, 0.64)	0.47 (0.38, 0.64)	0.49 (0.38, 0.64)	0.5 (0.37, 0.66)	0.48 (0.38, 0.66)
+-+–	rate	0.135 (0, 0.565)	0.154 (0, 0.696)	0.139 (0, 0.89)	0.135 (0, 0.562)	0.129 (0, 0.607)	0.127 (0, 0.688)
+-+-+	graduation	0	14	11	5	18	14
+-+-+	futility	0	58	59	71	17	66
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.56 (0.49, 0.59)	0.48 (0.48, 0.48)	0.48 (0.44, 0.52)	0.5 (0.5, 0.5)	0.47 (0.44, 0.5)
+-+-+	rate	0.184 (0, 1.462)	0.128 (0, 0.36)	0.08 (0, 0.355)	0.14 (0, 1.553)	0.252 (0, 1.653)	0.146 (0, 0.966)
+-++-	graduation	0	14	9	4	27	10
+-++-	futility	0	54	51	64	14	47
+-++-	max_n	0	0	0	0	0	0
+-++-	n	21 (15, 28)	7 (3, 17)	11 (5, 21)	8 (3, 18)	8 (3, 17)	8 (3, 18)
+-++-	n_unique	19 (13, 26)	7 (3, 16)	9 (4, 19)	7 (3, 17)	7 (3, 15)	7 (2, 16)
+-++-	post_p	NA (NA, NA)	0.42 (0.17, 0.8)	0.48 (0.18, 0.83)	0.47 (0.18, 0.84)	0.48 (0.17, 0.84)	0.46 (0.2, 0.82)
+-++-	rate	0.112 (0.085, 0.156)	0.13 (0.08, 0.296)	0.124 (0.081, 0.221)	0.124 (0.076, 0.299)	0.122 (0.076, 0.313)	0.125 (0.076, 0.303)
+-+++	graduation	0	17	14	5	28	16
+-+++	futility	0	72	69	82	17	74
+-+++	max_n	0	0	0	0	0	0
+-+++	n	15 (10, 22)	6 (2, 14)	7 (3, 15)	6 (2, 15)	7 (2, 15)	7 (3, 15)
+-+++	n_unique	14 (9, 21)	5 (2, 13)	7 (2, 14)	6 (2, 14)	6 (2, 14)	6 (2, 14)
+-+++	post_p	NA (NA, NA)	0.44 (0.19, 0.81)	0.47 (0.2, 0.84)	0.44 (0.2, 0.85)	0.46 (0.19, 0.82)	0.45 (0.18, 0.84)
+-+++	rate	0.11 (0.077, 0.167)	0.135 (0.074, 0.3)	0.121 (0.074, 0.284)	0.125 (0.073, 0.313)	0.129 (0.072, 0.343)	0.124 (0.075, 0.312)
++—	graduation	0	16	1	0	378	8
++—	futility	0	22	31	107	0	38
++—	max_n	0	0	0	0	0	0
++—	n	9 (5, 14)	4 (1, 8)	4 (1, 8)	3 (2, 6)	5 (1, 9)	4 (1, 8)
++—	n_unique	8 (4, 13)	3 (1, 7)	3 (1, 7)	3 (2, 5)	4 (1, 8)	3 (1, 7)
++—	post_p	NA (NA, NA)	0.42 (0.23, 0.75)	0.46 (0.24, 0.74)	0.25 (0.13, 0.44)	0.88 (0.57, 0.99)	0.44 (0.25, 0.73)
++—	rate	0.117 (0.068, 0.191)	0.136 (0.061, 0.374)	0.123 (0.057, 0.364)	0.256 (0.133, 0.576)	0.036 (0.011, 0.094)	0.131 (0.055, 0.38)
++–+	graduation	0	19	7	2	376	14
++–+	futility	0	49	57	132	3	72
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.47 (0.46, 0.49)	0.55 (0.55, 0.55)	0.46 (0.45, 0.47)	NA (NA, NA)	0.51 (0.44, 0.54)
++–+	rate	0.086 (0, 1.083)	0.118 (0, 0.427)	0.167 (0, 0.54)	0.591 (0.134, 3.051)	0.068 (0, 0.996)	0.081 (0, 0.279)
++-+-	graduation	0	19	4	0	382	11
++-+-	futility	0	39	45	126	1	50
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 3)	0 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 2)	1 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)	0 (0, 1)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.51 (0.4, 0.66)	0.47 (0.39, 0.6)	0.45 (0.34, 0.57)	0.57 (0.44, 0.67)	0.47 (0.4, 0.6)
++-+-	rate	0.125 (0, 0.52)	0.125 (0, 0.777)	0.14 (0, 0.977)	0.286 (0.066, 1.239)	0.042 (0, 0.193)	0.131 (0, 0.724)
++-++	graduation	0	22	10	2	380	17
++-++	futility	0	63	68	145	4	79
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.52 (0.52, 0.52)	0.48 (0.46, 0.54)	0.5 (0.45, 0.55)	NA (NA, NA)	0.48 (0.45, 0.5)
++-++	rate	0.097 (0, 0.885)	0.133 (0, 0.837)	0.142 (0.028, 1.122)	0.216 (0.075, 0.757)	0.038 (0, 0.073)	0.081 (0, 0.372)
+++–	graduation	0	18	6	3	370	11
+++–	futility	0	51	65	143	10	68
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.47 (0.42, 0.58)	0.53 (0.44, 0.57)	0.46 (0.42, 0.49)	0.55 (0.46, 0.58)	0.49 (0.43, 0.59)
+++–	rate	0.106 (0, 0.575)	0.129 (0, 1.032)	0.1 (0, 0.448)	0.323 (0.11, 1.815)	0.05 (0, 0.234)	0.149 (0, 1.039)
+++-+	graduation	0	20	11	4	369	17
+++-+	futility	0	71	83	158	12	92
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.51 (0.48, 0.54)	0.47 (0.45, 0.51)	0.48 (0.43, 0.5)	0.52 (0.5, 0.55)	0.43 (0.42, 0.48)
+++-+	rate	0.212 (0, 2.372)	0.2 (0, 4.669)	0.077 (0, 0.506)	0.358 (0.079, 0.888)	0.073 (0, 0.276)	0.136 (0, 1.602)
++++-	graduation	0	21	9	3	373	14
++++-	futility	0	66	76	151	11	76
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	0.53 (0.52, 0.54)
++++-	rate	0.072 (0, 0.527)	0.129 (0, 0.584)	0.162 (0, 2.513)	0.279 (0.106, 0.68)	0 (0, 0.17)	0.131 (0, 0.581)
+++++	graduation	0	23	14	4	372	20
+++++	futility	0	83	93	166	13	99
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	NA (NA, NA)	0.45 (0.41, 0.49)	0.46 (0.46, 0.46)	0.53 (0.48, 0.54)	0.56 (0.51, 0.6)
+++++	rate	0.103 (0, 1.092)	0.097 (0, 0.315)	0.228 (0.075, 1.206)	0.458 (0.1, 3.537)	0.042 (0, 0.675)	0.068 (0, 0.234)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	8	1		12	4
all	time_stop	6 (4, 8)	7 (7, 7)		7 (6, 9)	7 (7, 10)
all	n_trt	38 (29, 48)	28 (28, 28)		29 (26, 34)	32 (28, 46)
all	n_control	57 (44, 78)	79 (79, 79)		65 (58, 88)	69 (61, 91)
all	post_p	0.92 (0.87, 0.97)	0.91 (0.91, 0.91)		0.97 (0.93, 0.99)	0.93 (0.89, 0.97)
all	order	1 (1, 1)	1 (1, 1)		1 (1, 1.9)	1 (1, 1)
AR- & TP53-	count	35	23	1	69	10
AR- & TP53-	time_stop	7 (5, 11)	10 (7, 12)	13 (13, 13)	13 (9, 21)	10 (8, 13)
AR- & TP53-	n_trt	33 (25, 45)	30 (26, 34)	33 (33, 33)	35 (26, 64)	29 (25, 45)
AR- & TP53-	n_control	38 (27, 59)	44 (32, 70)	80 (80, 80)	71 (43, 116)	52 (43, 75)
AR- & TP53-	post_p	0.9 (0.85, 0.97)	0.94 (0.89, 0.97)	0.97 (0.97, 0.97)	0.99 (0.93, 1)	0.92 (0.88, 0.98)
AR- & TP53-	order	1 (1, 1)	1 (1, 1)	2 (2, 2)	1 (1, 2)	1 (1, 1.1)
HRD+	count	8			367	4
HRD+	time_stop	25 (20, 30)			20 (15, 30)	24 (21, 26)
HRD+	n_trt	26 (25, 32)			26 (25, 41)	26 (26, 28)
HRD+	n_control	40 (26, 58)			30 (19, 49)	30 (28, 34)
HRD+	post_p	0.94 (0.88, 1)			1 (0.99, 1)	0.96 (0.9, 0.99)
HRD+	order	2 (1.7, 3.3)			1 (1, 2)	2 (1.3, 3.4)
TP53+	count	3	5	4	5	3
TP53+	time_stop	14 (10, 14)	14 (13, 16)	15 (12, 18)	16 (15, 18)	13 (12, 14)
TP53+	n_trt	29 (27, 31)	28 (25, 31)	28 (26, 33)	29 (27, 33)	25 (25, 30)
TP53+	n_control	34 (29, 37)	39 (33, 45)	46 (38, 62)	43 (42, 49)	33 (30, 39)
TP53+	post_p	0.96 (0.96, 0.97)	0.96 (0.93, 0.98)	0.98 (0.9, 0.99)	0.99 (0.98, 1)	0.94 (0.9, 0.98)
TP53+	order	1 (1, 1)	1 (1, 2)	1.5 (1, 2.7)	1 (1, 2)	1 (1, 1.8)
TEfus+	count	3	3		12	3
TEfus+	time_stop	14 (13, 18)	13 (12, 19)		14 (12, 20)	15 (14, 17)
TEfus+	n_trt	31 (29, 32)	28 (26, 32)		26 (25, 38)	30 (27, 31)
TEfus+	n_control	41 (39, 53)	39 (38, 51)		40 (28, 67)	40 (31, 46)
TEfus+	post_p	0.94 (0.87, 0.94)	0.95 (0.89, 0.98)		0.98 (0.95, 1)	0.91 (0.88, 0.94)
TEfus+	order	1 (1, 1)	1 (1, 1)		1.5 (1, 2.9)	1 (1, 2.6)
PI3K+	count	4	6	2	4	7
PI3K+	time_stop	16 (14, 20)	17 (14, 22)	16 (14, 18)	19 (18, 22)	11 (9, 13)
PI3K+	n_trt	26 (25, 30)	28 (26, 37)	28 (26, 29)	32 (27, 34)	28 (26, 39)
PI3K+	n_control	46 (37, 59)	50 (38, 66)	54 (46, 62)	54 (46, 73)	27 (20, 39)
PI3K+	post_p	0.94 (0.92, 0.96)	0.97 (0.95, 0.99)	0.94 (0.91, 0.98)	0.99 (0.97, 0.99)	0.97 (0.89, 0.99)
PI3K+	order	2.5 (2, 3)	2 (1, 2)	3 (2.2, 3.8)	3 (2, 4)	1 (1, 1)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	4	2	4		6
all	time_stop	4 (4, 9)	6 (5, 7)	18 (10, 32)		11 (8, 18)
all	n_trt	30 (26, 45)	29 (27, 31)	72 (33, 97)		43 (25, 64)
all	n_control	50 (37, 84)	53 (50, 56)	170 (100, 347)		96 (66, 178)
all	post_p	0.05 (0.01, 0.17)	0.11 (0.04, 0.18)	0.02 (0.01, 0.04)		0.03 (0.01, 0.08)
all	order	1 (1, 1.7)	1 (1, 1)	2.5 (1, 4)		1 (1, 4.5)
AR- & TP53-	count	105	68	168	1	60
AR- & TP53-	time_stop	13 (6, 28)	17 (11, 28)	19 (12, 32)	13 (13, 13)	18 (12, 31)
AR- & TP53-	n_trt	36 (26, 78)	36 (25, 75)	37 (26, 74)	32 (32, 32)	42 (27, 76)
AR- & TP53-	n_control	62 (31, 164)	90 (59, 168)	101 (62, 189)	69 (69, 69)	108 (55, 185)
AR- & TP53-	post_p	0.14 (0.03, 0.26)	0.13 (0.03, 0.24)	0.07 (0.01, 0.16)	0.21 (0.21, 0.21)	0.1 (0.02, 0.27)
AR- & TP53-	order	1 (1, 2)	1 (1, 3)	1 (1, 3)	1 (1, 1)	1 (1, 2.1)
HRD+	count	18	29	103		32
HRD+	time_stop	30 (26, 34)	32 (25, 35)	31 (22, 35)		31 (24, 35)
HRD+	n_trt	29 (25, 37)	29 (25, 40)	25 (25, 27)		28 (25, 37)
HRD+	n_control	49 (40, 62)	55 (38, 66)	50 (31, 69)		50 (35, 62)
HRD+	post_p	0.15 (0.03, 0.29)	0.15 (0.05, 0.27)	0.01 (0, 0.07)		0.12 (0.03, 0.22)
HRD+	order	3.5 (2, 5)	2 (1, 4)	2 (1, 4)		2 (1, 4.9)
TP53+	count	33	38	49	14	34
TP53+	time_stop	22 (16, 31)	19 (15, 30)	25 (17, 32)	20 (18, 28)	21 (12, 33)
TP53+	n_trt	32 (25, 48)	32 (25, 47)	30 (26, 49)	30 (25, 42)	30 (25, 45)
TP53+	n_control	70 (46, 91)	58 (42, 90)	73 (49, 105)	62 (41, 94)	63 (32, 102)
TP53+	post_p	0.06 (0.01, 0.24)	0.07 (0.01, 0.16)	0.04 (0.01, 0.16)	0.06 (0.01, 0.21)	0.06 (0.01, 0.19)
TP53+	order	2 (1, 3.8)	2 (1, 3)	2 (1, 4)	2 (1, 3.7)	2 (1, 4)
TEfus+	count	20	15	26	1	15
TEfus+	time_stop	26 (19, 34)	25 (16, 31)	24 (17, 34)	33 (33, 33)	27 (16, 33)
TEfus+	n_trt	32 (25, 51)	31 (25, 40)	31 (25, 45)	28 (28, 28)	35 (26, 46)
TEfus+	n_control	76 (48, 107)	75 (40, 98)	71 (45, 124)	108 (108, 108)	72 (42, 105)
TEfus+	post_p	0.04 (0, 0.14)	0.06 (0.01, 0.22)	0.02 (0, 0.08)	0.12 (0.12, 0.12)	0.06 (0.03, 0.17)
TEfus+	order	3 (1, 5.1)	3 (1, 5)	2 (1, 4.5)	3 (3, 3)	3 (1, 4.6)
PI3K+	count	29	28	32	4	43
PI3K+	time_stop	25 (15, 34)	24 (18, 35)	24 (17, 32)	26 (21, 34)	17 (9, 27)
PI3K+	n_trt	30 (25, 44)	30 (26, 45)	32 (26, 44)	40 (28, 52)	31 (25, 41)
PI3K+	n_control	72 (37, 110)	82 (51, 108)	74 (45, 116)	86 (64, 104)	41 (17, 79)
PI3K+	post_p	0.06 (0.02, 0.16)	0.07 (0.01, 0.18)	0.06 (0.01, 0.19)	0.12 (0.1, 0.18)	0.08 (0.01, 0.25)
PI3K+	order	2 (1, 4)	2 (1, 4)	2 (1, 5)	2 (2, 2.7)	2 (1, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8
all	TC1	time	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)
all	TC1	n	19 (14, 25)	2 (0, 6)	0 (0, 1)	1 (0, 2)	4 (2, 6)	1 (0, 5)	0 (0, 1)	1 (1, 3)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (1, 3)	1 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.59 (0.56, 0.85)	0.56 (0.55, 0.62)	NA (NA, NA)	0.54 (0.51, 0.61)	0.57 (0.53, 0.64)	0.56 (0.53, 0.59)	0.52 (0.51, 0.56)	0.57 (0.52, 0.61)	0.55 (0.55, 0.61)	NA (NA, NA)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.52, 0.54)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.51, 0.62)	0.55 (0.51, 0.67)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.079 (0.048, 0.101)	0 (0, 0.045)	0 (0, 0)	0 (0, 0.288)	0 (0, 0.086)	0 (0, 0.116)	0 (0, 0)	0 (0, 0.069)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	1.842 (1.842, 1.842)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0.42)	0.208 (0.042, 0.374)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.031)	0 (0, 0.134)	0 (0, 2.187)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
all	TC2	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC2	time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
all	TC2	n	8 (8, 8)	3 (3, 3)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	4 (4, 4)	5 (5, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.72 (0.72, 0.72)	0.58 (0.58, 0.58)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.64 (0.64, 0.64)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.116 (0.116, 0.116)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.12 (0.12, 0.12)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.047 (0.047, 0.047)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12
all	TC4	time	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)
all	TC4	n	5 (3, 10)	1 (0, 4)	0 (0, 0)	1 (0, 2)	2 (0, 6)	2 (1, 6)	0 (0, 1)	1 (0, 2)	4 (3, 6)	0 (0, 0)	2 (0, 4)	1 (0, 1)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 0)	2 (0, 4)	2 (1, 3)	2 (1, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.57 (0.55, 0.72)	0.56 (0.53, 0.66)	0.55 (0.55, 0.55)	0.53 (0.51, 0.6)	0.63 (0.58, 0.7)	0.56 (0.52, 0.59)	0.51 (0.5, 0.53)	0.53 (0.52, 0.59)	0.66 (0.53, 0.79)	NA (NA, NA)	0.57 (0.54, 0.72)	0.59 (0.52, 0.77)	NA (NA, NA)	0.53 (0.51, 0.56)	NA (NA, NA)	0.52 (0.52, 0.52)	0.55 (0.52, 0.64)	0.61 (0.61, 0.61)	0.54 (0.52, 0.61)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	0.56 (0.53, 0.58)	0.56 (0.52, 0.66)	0.58 (0.54, 0.73)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.06 (0, 0.104)	0 (0, 0.121)	0 (0, 0)	0 (0, 0)	0 (0, 0.102)	0 (0, 0.082)	0.246 (0.045, 0.498)	0 (0, 0.068)	0 (0, 0.079)	NA (NA, NA)	0 (0, 0.069)	0 (0, 0.006)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.426)	0 (0, 0.023)	0 (0, 0.047)	0 (0, 0)	0.129 (0, 2.074)	NA (NA, NA)	0 (0, 0.109)	0 (0, 0.08)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0.161)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC5	time	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)	7 (7, 10)
all	TC5	n	6 (1, 9)	7 (5, 9)	0 (0, 1)	2 (0, 3)	2 (1, 2)	4 (2, 8)	0 (0, 1)	4 (2, 5)	2 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 3)	0 (0, 1)	0 (0, 0)	2 (0, 3)	3 (1, 4)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.71 (0.69, 0.83)	0.53 (0.52, 0.57)	0.63 (0.63, 0.63)	0.53 (0.52, 0.56)	0.55 (0.53, 0.63)	0.54 (0.54, 0.6)	0.57 (0.57, 0.57)	0.63 (0.6, 0.69)	0.6 (0.53, 0.74)	NA (NA, NA)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.55 (0.55, 0.55)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	0.53 (0.53, 0.54)	0.54 (0.52, 0.57)	0.58 (0.53, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0 (0, 0.039)	0.08 (0.064, 0.096)	0.373 (0.075, 0.671)	0.055 (0.011, 0.118)	0 (0, 0)	0.051 (0, 0.105)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.061 (0.012, 0.109)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.166 (0.033, 0.299)	0 (0, 0)	0.163 (0.163, 0.163)	0.206 (0.098, 0.314)	0 (0, 0)	NA (NA, NA)	0 (0, 0.087)	0.109 (0.086, 0.258)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	35	35	35	35					35	35	35	35
AR- & TP53-	TC1	time	7 (5, 11)	7 (5, 11)	7 (5, 11)	7 (5, 11)					7 (5, 11)	7 (5, 11)	7 (5, 11)	7 (5, 11)
AR- & TP53-	TC1	n	24 (20, 35)	3 (1, 5)	1 (0, 3)	1 (0, 3)					1 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 1)
AR- & TP53-	TC1	post_p	0.81 (0.73, 0.91)	0.58 (0.51, 0.71)	0.6 (0.54, 0.62)	0.54 (0.52, 0.64)					0.53 (0.51, 0.59)	NA (NA, NA)	0.55 (0.51, 0.63)	0.54 (0.51, 0.56)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.072 (0.055, 0.097)	0.051 (0, 0.108)	0 (0, 0.141)	0 (0, 0.346)					0 (0, 0.083)	NA (NA, NA)	0 (0, 0.1)	0 (0, 0.18)
AR- & TP53-	TC2	count	23	23	23	23					23	23	23	23
AR- & TP53-	TC2	time	10 (7, 12)	10 (7, 12)	10 (7, 12)	10 (7, 12)					10 (7, 12)	10 (7, 12)	10 (7, 12)	10 (7, 12)
AR- & TP53-	TC2	n	21 (18, 26)	3 (1, 5)	0 (0, 1)	1 (0, 4)					2 (0, 6)	0 (0, 0)	1 (0, 2)	0 (0, 1)
AR- & TP53-	TC2	post_p	0.85 (0.79, 0.92)	0.57 (0.51, 0.69)	0.55 (0.51, 0.71)	0.6 (0.52, 0.63)					0.61 (0.51, 0.78)	NA (NA, NA)	0.56 (0.54, 0.73)	0.54 (0.53, 0.59)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.07 (0.04, 0.094)	0 (0, 0.109)	0.04 (0, 0.63)	0 (0, 0.079)					0 (0, 0.085)	0.077 (0.077, 0.077)	0 (0, 0.035)	0 (0, 0.167)
AR- & TP53-	TC3	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC3	time	13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)					13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)
AR- & TP53-	TC3	n	23 (23, 23)	3 (3, 3)	1 (1, 1)	2 (2, 2)					3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)
AR- & TP53-	TC3	post_p	0.73 (0.73, 0.73)	0.84 (0.84, 0.84)	0.64 (0.64, 0.64)	0.7 (0.7, 0.7)					0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.087 (0.087, 0.087)	0 (0, 0)	0 (0, 0)	0.085 (0.085, 0.085)					0.091 (0.091, 0.091)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
AR- & TP53-	TC4	count	69	69	69	69					69	69	69	69
AR- & TP53-	TC4	time	13 (9, 21)	13 (9, 21)	13 (9, 21)	13 (9, 21)					13 (9, 21)	13 (9, 21)	13 (9, 21)	13 (9, 21)
AR- & TP53-	TC4	n	18 (11, 36)	4 (1, 14)	0 (0, 2)	2 (0, 4)					7 (4, 13)	0 (0, 0)	3 (1, 6)	1 (0, 3)
AR- & TP53-	TC4	post_p	0.78 (0.71, 0.92)	0.64 (0.53, 0.78)	0.57 (0.52, 0.65)	0.56 (0.52, 0.68)					0.83 (0.63, 0.97)	NA (NA, NA)	0.67 (0.56, 0.85)	0.6 (0.54, 0.74)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.079 (0.04, 0.101)	0.064 (0, 0.115)	0 (0, 0.385)	0 (0, 0.131)					0.03 (0, 0.058)	0 (0, 0)	0 (0, 0.071)	0 (0, 0.09)
AR- & TP53-	TC5	count	10	10	10	10					10	10	10	10
AR- & TP53-	TC5	time	10 (8, 13)	10 (8, 13)	10 (8, 13)	10 (8, 13)					10 (8, 13)	10 (8, 13)	10 (8, 13)	10 (8, 13)
AR- & TP53-	TC5	n	16 (13, 26)	6 (3, 13)	0 (0, 2)	3 (1, 5)					2 (1, 5)	0 (0, 0)	0 (0, 2)	0 (0, 2)
AR- & TP53-	TC5	post_p	0.79 (0.73, 0.92)	0.69 (0.53, 0.84)	0.57 (0.55, 0.59)	0.57 (0.53, 0.7)					0.58 (0.54, 0.68)	NA (NA, NA)	0.53 (0.53, 0.57)	0.55 (0.55, 0.56)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.062 (0.026, 0.103)	0.065 (0.037, 0.119)	0 (0, 0.15)	0.046 (0, 0.144)					0 (0, 0.1)	NA (NA, NA)	0 (0, 0.059)	0 (0, 0.316)
HRD+	TC1	count									8	8	8	8	8	8	8	8									8	8	8	8	8	8	8	8
HRD+	TC1	time									25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)									25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)	25 (20, 30)
HRD+	TC1	n									15 (12, 21)	0 (0, 0)	4 (2, 11)	2 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 2)									4 (1, 7)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.84 (0.74, 0.95)	NA (NA, NA)	0.73 (0.54, 0.86)	0.63 (0.62, 0.75)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)									0.66 (0.61, 0.78)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.063 (0.033, 0.121)	NA (NA, NA)	0.041 (0, 0.095)	0.036 (0, 0.098)	NA (NA, NA)	1.752 (1.752, 1.752)	NA (NA, NA)	0.064 (0.017, 0.253)									0.054 (0.036, 0.135)	0.103 (0.103, 0.103)	NA (NA, NA)	NA (NA, NA)	2.098 (2.098, 2.098)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									367	367	367	367	367	367	367	367									367	367	367	367	367	367	367	367
HRD+	TC4	time									20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)									20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)	20 (15, 30)
HRD+	TC4	n									13 (8, 20)	0 (0, 0)	5 (2, 10)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (1, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.96 (0.78, 1)	0.59 (0.59, 0.59)	0.8 (0.59, 0.97)	0.63 (0.52, 0.82)	0.54 (0.54, 0.54)	0.59 (0.52, 0.77)	0.53 (0.53, 0.53)	0.6 (0.52, 0.78)									0.72 (0.55, 0.93)	NA (NA, NA)	0.57 (0.51, 0.66)	NA (NA, NA)	0.55 (0.52, 0.59)	0.53 (0.53, 0.54)	NA (NA, NA)	0.52 (0.5, 0.54)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.032 (0.011, 0.061)	0 (0, 0.267)	0.032 (0, 0.079)	0.024 (0, 0.105)	0 (0, 0.182)	0 (0, 0.127)	0 (0, 0.226)	0 (0, 0.09)									0.029 (0, 0.088)	0.112 (0, 1.093)	0 (0, 0.153)	0 (0, 0.014)	0 (0, 0.294)	0 (0, 0.291)	0 (0, 0.192)	0 (0, 0.66)
HRD+	TC5	count									4	4	4	4	4	4	4	4									4	4	4	4	4	4	4	4
HRD+	TC5	time									24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)									24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)	24 (21, 26)
HRD+	TC5	n									13 (11, 17)	0 (0, 1)	4 (2, 5)	2 (0, 2)	0 (0, 0)	0 (0, 3)	0 (0, 0)	2 (1, 2)									4 (3, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.78 (0.72, 0.9)	NA (NA, NA)	0.63 (0.59, 0.67)	0.65 (0.64, 0.67)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.6 (0.54, 0.65)									0.66 (0.53, 0.78)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.07 (0.048, 0.079)	0 (0, 0)	0.026 (0, 0.119)	0 (0, 0.053)	NA (NA, NA)	0.411 (0.156, 0.667)	NA (NA, NA)	0.173 (0.052, 0.236)									0.086 (0.062, 0.111)	NA (NA, NA)	0.041 (0.041, 0.041)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC1	time					14 (10, 14)	14 (10, 14)	14 (10, 14)	14 (10, 14)					14 (10, 14)	14 (10, 14)	14 (10, 14)	14 (10, 14)					14 (10, 14)	14 (10, 14)	14 (10, 14)	14 (10, 14)					14 (10, 14)	14 (10, 14)	14 (10, 14)	14 (10, 14)
TP53+	TC1	n					9 (8, 10)	5 (4, 5)	2 (0, 4)	7 (3, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 1)	3 (3, 6)	3 (1, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.75 (0.71, 0.84)	0.53 (0.52, 0.64)	0.52 (0.52, 0.53)	0.76 (0.66, 0.77)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.72 (0.7, 0.78)	0.66 (0.55, 0.77)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.049 (0.048, 0.097)	0.105 (0.049, 0.119)	0.033 (0.007, 0.059)	0.037 (0.007, 0.051)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	0 (0, 0)	0 (0, 0.026)	0 (0, 0.029)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					5	5	5	5					5	5	5	5					5	5	5	5					5	5	5	5
TP53+	TC2	time					14 (13, 16)	14 (13, 16)	14 (13, 16)	14 (13, 16)					14 (13, 16)	14 (13, 16)	14 (13, 16)	14 (13, 16)					14 (13, 16)	14 (13, 16)	14 (13, 16)	14 (13, 16)					14 (13, 16)	14 (13, 16)	14 (13, 16)	14 (13, 16)
TP53+	TC2	n					5 (3, 10)	5 (3, 8)	1 (0, 3)	5 (3, 5)					0 (0, 0)	0 (0, 1)	0 (0, 1)	1 (0, 2)					1 (0, 1)	0 (0, 0)	5 (4, 6)	3 (2, 4)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.6 (0.56, 0.75)	0.69 (0.6, 0.8)	0.55 (0.54, 0.6)	0.64 (0.54, 0.68)					NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	0.55 (0.55, 0.56)					NA (NA, NA)	NA (NA, NA)	0.81 (0.62, 0.83)	0.55 (0.52, 0.61)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.081 (0.034, 0.092)	0.04 (0, 0.089)	0 (0, 0.015)	0.039 (0.014, 0.129)					NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.079 (0.016, 0.108)					0 (0, 0.116)	NA (NA, NA)	0.049 (0.014, 0.081)	0.11 (0.049, 0.203)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					4	4	4	4					4	4	4	4					4	4	4	4					4	4	4	4
TP53+	TC3	time					15 (12, 18)	15 (12, 18)	15 (12, 18)	15 (12, 18)					15 (12, 18)	15 (12, 18)	15 (12, 18)	15 (12, 18)					15 (12, 18)	15 (12, 18)	15 (12, 18)	15 (12, 18)					15 (12, 18)	15 (12, 18)	15 (12, 18)	15 (12, 18)
TP53+	TC3	n					6 (4, 7)	4 (3, 5)	2 (0, 4)	5 (4, 8)					0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 1)					0 (0, 1)	0 (0, 0)	6 (3, 8)	4 (3, 6)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.7 (0.51, 0.89)	0.59 (0.54, 0.72)	0.7 (0.68, 0.73)	0.62 (0.54, 0.71)					NA (NA, NA)	0.51 (0.5, 0.51)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.71 (0.69, 0.79)	0.74 (0.64, 0.79)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.074 (0.043, 0.091)	0.055 (0, 0.112)	0.014 (0.003, 0.025)	0.089 (0.061, 0.113)					NA (NA, NA)	0.082 (0.016, 0.133)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0.052 (0.014, 0.061)	0.015 (0, 0.037)					0.114 (0.023, 0.206)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					5	5	5	5					5	5	5	5					5	5	5	5					5	5	5	5
TP53+	TC4	time					16 (15, 18)	16 (15, 18)	16 (15, 18)	16 (15, 18)					16 (15, 18)	16 (15, 18)	16 (15, 18)	16 (15, 18)					16 (15, 18)	16 (15, 18)	16 (15, 18)	16 (15, 18)					16 (15, 18)	16 (15, 18)	16 (15, 18)	16 (15, 18)
TP53+	TC4	n					7 (5, 10)	5 (4, 7)	0 (0, 3)	4 (0, 5)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 4)	0 (0, 0)	7 (2, 9)	4 (1, 7)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.77 (0.71, 0.89)	0.72 (0.59, 0.82)	0.53 (0.51, 0.56)	0.52 (0.5, 0.68)					NA (NA, NA)	0.59 (0.59, 0.59)	NA (NA, NA)	0.64 (0.62, 0.65)					0.72 (0.72, 0.72)	NA (NA, NA)	0.83 (0.72, 0.86)	0.75 (0.63, 0.87)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.059 (0.023, 0.066)	0.053 (0.014, 0.085)	0.043 (0.009, 0.077)	0.13 (0.07, 0.151)					NA (NA, NA)	0 (0, 0.043)	NA (NA, NA)	0 (0, 0)					0.1 (0.071, 0.13)	NA (NA, NA)	0.039 (0.026, 0.053)	0.019 (0, 0.062)					0.597 (0.119, 1.074)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC5	time					13 (12, 14)	13 (12, 14)	13 (12, 14)	13 (12, 14)					13 (12, 14)	13 (12, 14)	13 (12, 14)	13 (12, 14)					13 (12, 14)	13 (12, 14)	13 (12, 14)	13 (12, 14)					13 (12, 14)	13 (12, 14)	13 (12, 14)	13 (12, 14)
TP53+	TC5	n					4 (2, 8)	5 (5, 7)	2 (0, 2)	8 (7, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 1)	0 (0, 0)	4 (3, 4)	3 (2, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.55 (0.55, 0.73)	0.58 (0.56, 0.72)	0.61 (0.59, 0.63)	0.8 (0.74, 0.89)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0.53 (0.53, 0.53)	NA (NA, NA)	0.56 (0.54, 0.57)	0.56 (0.52, 0.76)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.026 (0.005, 0.093)	0.101 (0.056, 0.14)	0 (0, 0)	0.054 (0.053, 0.072)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0 (0, 0)	NA (NA, NA)	0.133 (0.088, 0.146)	0.111 (0.058, 0.113)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC1	time			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)			14 (13, 18)	14 (13, 18)
TEfus+	TC1	n			3 (1, 3)	1 (0, 3)			2 (2, 3)	5 (3, 5)			3 (1, 4)	1 (1, 3)			0 (0, 0)	1 (0, 2)			2 (0, 4)	2 (0, 4)			5 (1, 8)	5 (4, 7)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.61 (0.61, 0.61)	0.53 (0.53, 0.54)			0.57 (0.52, 0.66)	0.71 (0.67, 0.8)			0.58 (0.54, 0.6)	0.57 (0.56, 0.67)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	0.54 (0.54, 0.54)			0.71 (0.62, 0.8)	0.72 (0.71, 0.73)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.101 (0.02, 0.182)	0.206 (0.198, 0.214)			0.056 (0.011, 0.08)	0.037 (0.007, 0.053)			0.124 (0.025, 0.128)	0 (0, 0.04)			NA (NA, NA)	0 (0, 0)			0.204 (0.092, 0.316)	0.106 (0.08, 0.132)			0.108 (0.083, 0.133)	0.06 (0.012, 0.073)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC2	time			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)			13 (12, 19)	13 (12, 19)
TEfus+	TC2	n			1 (1, 2)	2 (1, 2)			4 (2, 4)	4 (2, 7)			2 (2, 4)	0 (0, 0)			0 (0, 0)	0 (0, 1)			4 (2, 4)	0 (0, 2)			5 (4, 7)	5 (5, 6)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.52 (0.52, 0.52)	0.54 (0.52, 0.57)			0.54 (0.52, 0.55)	0.6 (0.56, 0.74)			0.66 (0.56, 0.7)	NA (NA, NA)			NA (NA, NA)	0.58 (0.58, 0.58)			0.66 (0.54, 0.78)	0.51 (0.51, 0.51)			0.67 (0.56, 0.78)	0.72 (0.7, 0.9)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.153 (0.031, 0.161)	0 (0, 0.117)			0.082 (0.016, 0.122)	0.046 (0.009, 0.082)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)			0.172 (0.102, 0.201)	0.05 (0.05, 0.05)			0.063 (0.061, 0.074)	0.053 (0.011, 0.061)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			12	12			12	12			12	12			12	12			12	12			12	12			12	12			12	12
TEfus+	TC4	time			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)
TEfus+	TC4	n			0 (0, 2)	3 (1, 4)			2 (0, 3)	4 (0, 5)			4 (3, 7)	1 (0, 4)			0 (0, 0)	1 (0, 2)			1 (0, 3)	0 (0, 2)			6 (3, 12)	4 (0, 7)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.58 (0.54, 0.61)	0.59 (0.51, 0.68)			0.56 (0.52, 0.76)	0.57 (0.5, 0.73)			0.71 (0.64, 0.87)	0.62 (0.56, 0.66)			NA (NA, NA)	0.6 (0.53, 0.8)			0.62 (0.59, 0.72)	0.52 (0.52, 0.59)			0.76 (0.61, 0.86)	0.68 (0.52, 0.77)			0.59 (0.59, 0.59)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0.025)	0.063 (0, 0.134)			0.087 (0, 0.194)	0.063 (0, 0.12)			0.017 (0, 0.051)	0 (0, 0.033)			0 (0, 0)	0 (0, 0.023)			0 (0, 0.152)	0 (0, 0.039)			0.051 (0.003, 0.086)	0.038 (0, 0.091)			0.048 (0.01, 0.1)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC5	time			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)			15 (14, 17)	15 (14, 17)
TEfus+	TC5	n			2 (0, 3)	2 (2, 4)			0 (0, 2)	9 (7, 11)			3 (2, 5)	1 (1, 1)			0 (0, 0)	1 (0, 2)			2 (1, 5)	0 (0, 2)			2 (1, 3)	4 (1, 4)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.6 (0.57, 0.63)	0.52 (0.52, 0.59)			0.52 (0.52, 0.52)	0.75 (0.71, 0.79)			0.58 (0.52, 0.63)	0.53 (0.51, 0.67)			NA (NA, NA)	NA (NA, NA)			0.71 (0.63, 0.79)	NA (NA, NA)			0.53 (0.51, 0.67)	0.56 (0.56, 0.56)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.037 (0.007, 0.066)	0.046 (0.046, 0.12)			0.091 (0.091, 0.091)	0.068 (0.057, 0.093)			0.039 (0.008, 0.088)	0 (0, 0)			NA (NA, NA)	0.091 (0.018, 0.163)			0.035 (0.007, 0.078)	0.166 (0.166, 0.166)			0.079 (0.016, 0.106)	0.093 (0.061, 0.125)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4
PI3K+	TC1	time		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)		16 (14, 20)
PI3K+	TC1	n		6 (3, 14)		2 (1, 4)		6 (5, 8)		6 (3, 8)		0 (0, 0)		0 (0, 1)		0 (0, 1)		0 (0, 1)		0 (0, 2)		1 (0, 1)		0 (0, 1)		2 (0, 4)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.73 (0.61, 0.9)		0.56 (0.53, 0.6)		0.72 (0.68, 0.72)		0.69 (0.61, 0.76)		NA (NA, NA)		0.55 (0.55, 0.55)		0.59 (0.59, 0.59)		NA (NA, NA)		0.54 (0.54, 0.54)		0.63 (0.63, 0.63)		NA (NA, NA)		0.7 (0.56, 0.77)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.074 (0.057, 0.092)		0.086 (0.058, 0.104)		0.053 (0.039, 0.086)		0.066 (0.045, 0.084)		NA (NA, NA)		0.058 (0.058, 0.058)		0 (0, 0)		0 (0, 0)		0.083 (0.017, 0.15)		0 (0, 0)		0 (0, 0)		0.043 (0.009, 0.097)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		6		6		6		6		6		6		6		6		6		6		6		6		6		6		6		6
PI3K+	TC2	time		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)		17 (14, 22)
PI3K+	TC2	n		6 (2, 10)		4 (1, 4)		5 (4, 8)		4 (3, 5)		0 (0, 0)		1 (0, 2)		1 (0, 2)		0 (0, 1)		1 (0, 2)		2 (0, 2)		0 (0, 0)		7 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.73 (0.55, 0.82)		0.55 (0.51, 0.75)		0.71 (0.63, 0.86)		0.64 (0.62, 0.67)		NA (NA, NA)		0.64 (0.59, 0.68)		0.54 (0.51, 0.57)		0.6 (0.59, 0.61)		0.59 (0.59, 0.59)		0.54 (0.53, 0.61)		NA (NA, NA)		0.81 (0.68, 0.9)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.081 (0.039, 0.097)		0.1 (0.035, 0.119)		0.062 (0.032, 0.084)		0.072 (0.041, 0.094)		NA (NA, NA)		0.032 (0, 0.072)		0 (0, 0.07)		0 (0, 0.529)		0.091 (0.02, 0.136)		0.069 (0.013, 0.107)		NA (NA, NA)		0.053 (0.022, 0.072)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC3	time		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)
PI3K+	TC3	n		8 (5, 12)		2 (2, 3)		6 (5, 7)		4 (3, 5)		0 (0, 0)		0 (0, 1)		0 (0, 1)		1 (0, 2)		0 (0, 1)		0 (0, 1)		0 (0, 0)		4 (2, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.68 (0.58, 0.77)		0.56 (0.56, 0.56)		0.69 (0.59, 0.79)		0.61 (0.58, 0.64)		NA (NA, NA)		0.54 (0.54, 0.54)		0.5 (0.5, 0.5)		0.55 (0.55, 0.55)		NA (NA, NA)		0.73 (0.73, 0.73)		NA (NA, NA)		0.68 (0.62, 0.75)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.094 (0.065, 0.122)		0.069 (0.061, 0.077)		0.072 (0.038, 0.105)		0.027 (0.005, 0.049)		NA (NA, NA)		0 (0, 0)		0.082 (0.082, 0.082)		0.124 (0.124, 0.124)		0.128 (0.128, 0.128)		0 (0, 0)		NA (NA, NA)		0.015 (0.003, 0.027)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4
PI3K+	TC4	time		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)		19 (18, 22)
PI3K+	TC4	n		10 (6, 11)		0 (0, 3)		6 (4, 10)		2 (0, 5)		0 (0, 0)		3 (1, 4)		1 (0, 2)		0 (0, 1)		1 (0, 2)		0 (0, 2)		0 (0, 0)		5 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.74 (0.71, 0.8)		0.54 (0.53, 0.55)		0.69 (0.63, 0.91)		0.72 (0.71, 0.73)		NA (NA, NA)		0.65 (0.63, 0.71)		0.55 (0.55, 0.56)		0.66 (0.66, 0.66)		0.54 (0.54, 0.54)		0.59 (0.59, 0.59)		NA (NA, NA)		0.79 (0.66, 0.86)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.062 (0.037, 0.068)		0.104 (0.076, 0.131)		0.058 (0.037, 0.08)		0.047 (0.044, 0.05)		NA (NA, NA)		0.029 (0.006, 0.034)		0.059 (0.012, 0.063)		0 (0, 0)		0 (0, 0.074)		0.133 (0.027, 0.24)		NA (NA, NA)		0.06 (0.048, 0.07)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		7		7		7		7		7		7		7		7		7		7		7		7		7		7		7		7
PI3K+	TC5	time		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)
PI3K+	TC5	n		8 (6, 12)		3 (1, 5)		5 (4, 8)		5 (2, 8)		0 (0, 0)		0 (0, 1)		0 (0, 1)		0 (0, 0)		1 (0, 1)		3 (0, 3)		0 (0, 0)		5 (3, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.81 (0.67, 0.9)		0.68 (0.54, 0.79)		0.64 (0.58, 0.72)		0.62 (0.56, 0.81)		NA (NA, NA)		0.53 (0.52, 0.54)		0.53 (0.53, 0.53)		NA (NA, NA)		0.51 (0.5, 0.52)		0.64 (0.56, 0.73)		NA (NA, NA)		0.66 (0.53, 0.76)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.074 (0.047, 0.113)		0.055 (0, 0.089)		0.071 (0, 0.099)		0.048 (0, 0.073)		NA (NA, NA)		0 (0, 0)		0.235 (0.047, 0.423)		0.275 (0.275, 0.275)		0 (0, 0)		0.063 (0, 0.142)		NA (NA, NA)		0.108 (0.019, 0.132)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC1	time	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)	4 (4, 9)
all	TC1	n	17 (13, 24)	4 (1, 5)	0 (0, 1)	1 (0, 2)	2 (1, 5)	0 (0, 2)	2 (1, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (0, 4)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.21 (0.11, 0.33)	0.44 (0.39, 0.47)	NA (NA, NA)	0.47 (0.39, 0.49)	0.45 (0.41, 0.48)	0.48 (0.48, 0.48)	0.37 (0.21, 0.46)	0.4 (0.4, 0.4)	0.39 (0.39, 0.39)	NA (NA, NA)	0.38 (0.38, 0.38)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	0.46 (0.45, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.38 (0.36, 0.39)	0.43 (0.43, 0.43)	0.47 (0.46, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.179 (0.131, 0.212)	0.084 (0.079, 0.304)	6.854 (6.854, 6.854)	0.107 (0.021, 0.228)	0.225 (0.02, 0.864)	0.035 (0.007, 0.063)	0.242 (0.065, 0.316)	1.607 (1.607, 1.607)	1.264 (1.264, 1.264)	NA (NA, NA)	0.314 (0.063, 0.566)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.188 (0.149, 0.227)	NA (NA, NA)	0.43 (0.086, 0.774)	NA (NA, NA)	0.244 (0.049, 0.774)	0.185 (0.185, 0.185)	0.2 (0.04, 0.36)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC2	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
all	TC2	n	10 (8, 12)	0 (0, 0)	0 (0, 1)	0 (0, 1)	3 (1, 5)	0 (0, 1)	1 (0, 2)	0 (0, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	5 (5, 5)	2 (2, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.28 (0.26, 0.3)	NA (NA, NA)	0.41 (0.41, 0.41)	0.46 (0.46, 0.46)	0.44 (0.43, 0.44)	0.39 (0.39, 0.39)	NA (NA, NA)	0.5 (0.5, 0.5)	0.46 (0.44, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.41 (0.41, 0.41)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.42 (0.37, 0.46)	0.33 (0.21, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.132 (0.13, 0.135)	NA (NA, NA)	0.199 (0.199, 0.199)	0 (0, 0)	0.276 (0.173, 0.378)	0.544 (0.544, 0.544)	0 (0, 0)	0 (0, 0)	1.791 (0.358, 3.224)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	8.289 (8.289, 8.289)	0 (0, 0)	0 (0, 0)	2.071 (0.497, 3.645)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.084 (0.073, 0.095)	0.184 (0.037, 0.332)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC3	time	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)
all	TC3	n	30 (12, 39)	2 (2, 5)	0 (0, 1)	0 (0, 1)	3 (2, 6)	5 (2, 6)	0 (0, 1)	2 (0, 5)	4 (3, 4)	0 (0, 0)	1 (1, 5)	0 (0, 2)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 1)	1 (1, 3)	0 (0, 1)	0 (0, 2)	0 (0, 1)	1 (0, 2)	0 (0, 1)	5 (1, 9)	4 (0, 8)	3 (2, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.27 (0.21, 0.34)	0.41 (0.16, 0.48)	NA (NA, NA)	0.44 (0.44, 0.44)	0.36 (0.23, 0.44)	0.36 (0.14, 0.47)	0.46 (0.46, 0.46)	0.45 (0.44, 0.46)	0.27 (0.27, 0.3)	NA (NA, NA)	0.37 (0.23, 0.44)	0.38 (0.38, 0.38)	NA (NA, NA)	0.46 (0.45, 0.46)	NA (NA, NA)	0.43 (0.43, 0.43)	0.43 (0.37, 0.47)	0.47 (0.47, 0.47)	0.38 (0.33, 0.43)	0.4 (0.4, 0.4)	0.46 (0.46, 0.46)	NA (NA, NA)	0.31 (0.17, 0.44)	0.27 (0.22, 0.36)	0.26 (0.26, 0.4)	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.13 (0.116, 0.168)	0.178 (0.163, 0.227)	0 (0, 0)	0.283 (0.283, 0.283)	0.159 (0.134, 0.232)	0.179 (0.126, 0.245)	0.315 (0.315, 0.315)	0.198 (0.128, 0.267)	0.288 (0.233, 0.394)	NA (NA, NA)	0.19 (0.16, 0.46)	3.341 (0.915, 5.767)	NA (NA, NA)	0.21 (0.176, 0.406)	NA (NA, NA)	0.156 (0.156, 0.156)	0.153 (0.038, 0.437)	0.065 (0.065, 0.065)	0.323 (0.14, 0.506)	0.151 (0.151, 0.151)	0.427 (0.172, 0.593)	0 (0, 0)	0.147 (0.129, 0.293)	0.183 (0.166, 0.202)	0.277 (0.174, 0.362)	NA (NA, NA)	0.581 (0.293, 0.869)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
all	TC5	time	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)	11 (8, 18)
all	TC5	n	6 (2, 15)	4 (3, 8)	0 (0, 1)	2 (1, 4)	2 (0, 6)	6 (4, 8)	0 (0, 0)	6 (4, 8)	1 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 2)	2 (0, 2)	0 (0, 0)	0 (0, 0)	2 (0, 4)	3 (1, 6)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.34 (0.11, 0.45)	0.41 (0.29, 0.46)	0.5 (0.5, 0.5)	0.41 (0.34, 0.49)	0.44 (0.33, 0.46)	0.37 (0.26, 0.4)	0.37 (0.37, 0.37)	0.4 (0.26, 0.49)	0.41 (0.35, 0.48)	NA (NA, NA)	0.45 (0.44, 0.46)	0.43 (0.39, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)	0.46 (0.46, 0.46)	0.41 (0.39, 0.43)	0.38 (0.33, 0.43)	0.41 (0.41, 0.41)	NA (NA, NA)	0.37 (0.34, 0.42)	0.36 (0.24, 0.43)	0.36 (0.36, 0.36)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.168 (0.128, 0.409)	0.173 (0.118, 0.227)	0.45 (0.09, 0.81)	0.148 (0.096, 0.793)	0.193 (0.14, 0.28)	0.163 (0.122, 0.322)	1.908 (1.908, 1.908)	0.145 (0.052, 0.259)	0.335 (0.04, 4.392)	NA (NA, NA)	0.146 (0.095, 0.198)	0.941 (0.407, 1.475)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.34 (0.311, 0.369)	0.049 (0.01, 0.059)	0.31 (0.307, 1.457)	0.241 (0.064, 0.273)	0.135 (0.135, 0.135)	NA (NA, NA)	0.33 (0.153, 0.866)	0.223 (0.106, 0.737)	0.101 (0.101, 0.101)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	105	105	105	105					105	105	105	105
AR- & TP53-	TC1	time	13 (6, 28)	13 (6, 28)	13 (6, 28)	13 (6, 28)					13 (6, 28)	13 (6, 28)	13 (6, 28)	13 (6, 28)
AR- & TP53-	TC1	n	23 (17, 49)	5 (2, 12)	1 (0, 3)	2 (0, 4)					3 (0, 9)	0 (0, 0)	2 (0, 5)	0 (0, 2)
AR- & TP53-	TC1	post_p	0.31 (0.1, 0.45)	0.38 (0.17, 0.48)	0.45 (0.31, 0.49)	0.42 (0.27, 0.49)					0.41 (0.21, 0.48)	NA (NA, NA)	0.41 (0.24, 0.49)	0.45 (0.39, 0.49)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.128 (0.102, 0.18)	0.164 (0.102, 0.577)	0.221 (0.09, 0.654)	0.204 (0.083, 0.712)					0.17 (0.104, 0.551)	0.232 (0.047, 0.329)	0.194 (0.025, 0.556)	0.152 (0, 0.937)
AR- & TP53-	TC2	count	68	68	68	68					68	68	68	68
AR- & TP53-	TC2	time	17 (11, 28)	17 (11, 28)	17 (11, 28)	17 (11, 28)					17 (11, 28)	17 (11, 28)	17 (11, 28)	17 (11, 28)
AR- & TP53-	TC2	n	20 (11, 50)	5 (2, 11)	1 (0, 3)	2 (0, 6)					4 (1, 10)	0 (0, 0)	2 (1, 5)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.3 (0.13, 0.48)	0.38 (0.25, 0.48)	0.42 (0.32, 0.49)	0.41 (0.25, 0.49)					0.36 (0.17, 0.48)	0.47 (0.47, 0.47)	0.41 (0.28, 0.49)	0.42 (0.33, 0.47)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.13 (0.106, 0.163)	0.173 (0.111, 0.323)	0.203 (0.075, 0.935)	0.203 (0.092, 0.736)					0.175 (0.105, 0.44)	4.614 (1.003, 8.226)	0.186 (0.095, 0.964)	0.222 (0.106, 0.83)
AR- & TP53-	TC3	count	168	168	168	168					168	168	168	168
AR- & TP53-	TC3	time	19 (12, 32)	19 (12, 32)	19 (12, 32)	19 (12, 32)					19 (12, 32)	19 (12, 32)	19 (12, 32)	19 (12, 32)
AR- & TP53-	TC3	n	17 (8, 50)	5 (2, 11)	1 (0, 3)	2 (0, 7)					5 (3, 9)	0 (0, 0)	3 (1, 6)	2 (0, 3)
AR- & TP53-	TC3	post_p	0.37 (0.14, 0.48)	0.38 (0.17, 0.47)	0.43 (0.31, 0.49)	0.4 (0.26, 0.48)					0.22 (0.08, 0.39)	0.48 (0.48, 0.48)	0.32 (0.12, 0.44)	0.4 (0.23, 0.47)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.131 (0.104, 0.192)	0.163 (0.11, 0.357)	0.181 (0.079, 0.642)	0.187 (0.11, 0.834)					0.234 (0.136, 0.502)	0.47 (0.039, 1.234)	0.266 (0.136, 0.61)	0.277 (0.133, 0.886)
AR- & TP53-	TC4	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC4	time	13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)					13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)
AR- & TP53-	TC4	n	19 (19, 19)	3 (3, 3)	0 (0, 0)	2 (2, 2)					4 (4, 4)	0 (0, 0)	2 (2, 2)	2 (2, 2)
AR- & TP53-	TC4	post_p	0.47 (0.47, 0.47)	0.45 (0.45, 0.45)	NA (NA, NA)	0.48 (0.48, 0.48)					0.36 (0.36, 0.36)	NA (NA, NA)	0.33 (0.33, 0.33)	NA (NA, NA)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.119 (0.119, 0.119)	0.148 (0.148, 0.148)	NA (NA, NA)	0.129 (0.129, 0.129)					0.202 (0.202, 0.202)	NA (NA, NA)	0.636 (0.636, 0.636)	0 (0, 0)
AR- & TP53-	TC5	count	60	60	60	60					60	60	60	60
AR- & TP53-	TC5	time	18 (12, 31)	18 (12, 31)	18 (12, 31)	18 (12, 31)					18 (12, 31)	18 (12, 31)	18 (12, 31)	18 (12, 31)
AR- & TP53-	TC5	n	19 (10, 47)	8 (3, 15)	1 (0, 2)	4 (2, 7)					5 (2, 14)	0 (0, 0)	3 (0, 7)	1 (0, 3)
AR- & TP53-	TC5	post_p	0.36 (0.13, 0.45)	0.34 (0.12, 0.47)	0.41 (0.33, 0.5)	0.41 (0.2, 0.49)					0.38 (0.16, 0.48)	NA (NA, NA)	0.4 (0.21, 0.49)	0.42 (0.35, 0.47)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.126 (0.102, 0.178)	0.164 (0.114, 0.281)	0.205 (0, 0.789)	0.164 (0.109, 0.41)					0.157 (0.101, 0.524)	NA (NA, NA)	0.178 (0.104, 0.538)	0.245 (0.066, 0.757)
HRD+	TC1	count									18	18	18	18	18	18	18	18									18	18	18	18	18	18	18	18
HRD+	TC1	time									30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)									30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)	30 (26, 34)
HRD+	TC1	n									10 (6, 18)	0 (0, 0)	6 (4, 14)	2 (1, 4)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 3)									4 (1, 8)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.29 (0.13, 0.47)	NA (NA, NA)	0.33 (0.21, 0.43)	0.4 (0.23, 0.47)	NA (NA, NA)	0.38 (0.34, 0.48)	NA (NA, NA)	0.39 (0.31, 0.48)									0.39 (0.23, 0.49)	NA (NA, NA)	0.43 (0.37, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.161 (0.115, 0.244)	0 (0, 0)	0.15 (0.083, 0.322)	0.256 (0.112, 0.433)	NA (NA, NA)	0.291 (0.14, 0.632)	NA (NA, NA)	0.272 (0.082, 0.643)									0.158 (0.118, 0.496)	0.143 (0.029, 0.257)	0.1 (0, 0.438)	NA (NA, NA)	0.192 (0.086, 0.281)	7.003 (7.003, 7.003)	0.663 (0.663, 0.663)	NA (NA, NA)
HRD+	TC2	count									29	29	29	29	29	29	29	29									29	29	29	29	29	29	29	29
HRD+	TC2	time									32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)									32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)	32 (25, 35)
HRD+	TC2	n									12 (6, 21)	0 (0, 0)	7 (2, 10)	3 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (1, 4)									3 (1, 8)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.4 (0.13, 0.47)	NA (NA, NA)	0.36 (0.2, 0.47)	0.4 (0.17, 0.49)	NA (NA, NA)	0.42 (0.37, 0.48)	NA (NA, NA)	0.45 (0.43, 0.49)									0.37 (0.2, 0.46)	NA (NA, NA)	0.42 (0.36, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.36 (0.36, 0.36)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.131 (0.1, 0.192)	4.707 (1.169, 8.244)	0.151 (0.1, 0.328)	0.21 (0.114, 0.391)	NA (NA, NA)	0.193 (0.069, 0.743)	0.174 (0.035, 0.313)	0.184 (0.037, 0.624)									0.171 (0.099, 0.637)	0.167 (0.167, 0.167)	0.167 (0.017, 0.872)	NA (NA, NA)	0 (0, 0.341)	NA (NA, NA)	0.293 (0.186, 0.401)	0.127 (0.127, 0.127)
HRD+	TC3	count									103	103	103	103	103	103	103	103									103	103	103	103	103	103	103	103
HRD+	TC3	time									31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)									31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)
HRD+	TC3	n									8 (5, 12)	0 (0, 0)	5 (3, 9)	3 (1, 5)	0 (0, 0)	2 (0, 4)	0 (0, 0)	2 (0, 4)									4 (2, 7)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.16 (0.07, 0.36)	0.48 (0.47, 0.49)	0.24 (0.12, 0.44)	0.36 (0.21, 0.48)	NA (NA, NA)	0.4 (0.28, 0.47)	NA (NA, NA)	0.39 (0.27, 0.47)									0.28 (0.11, 0.46)	NA (NA, NA)	0.41 (0.35, 0.47)	NA (NA, NA)	0.47 (0.43, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.205 (0.145, 0.296)	0.3 (0.065, 0.796)	0.23 (0.143, 0.546)	0.229 (0.129, 0.616)	0.199 (0.139, 0.499)	0.315 (0.136, 0.93)	0.119 (0.086, 0.294)	0.247 (0.139, 0.755)									0.234 (0.123, 0.473)	0.484 (0.109, 2.216)	0.325 (0.109, 1.257)	0.672 (0.634, 0.71)	0.347 (0, 0.769)	NA (NA, NA)	0.355 (0.091, 0.812)	0.82 (0.622, 1.018)
HRD+	TC5	count									32	32	32	32	32	32	32	32									32	32	32	32	32	32	32	32
HRD+	TC5	time									31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)									31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)
HRD+	TC5	n									13 (7, 20)	0 (0, 0)	4 (3, 10)	2 (0, 4)	0 (0, 0)	2 (0, 4)	0 (0, 0)	1 (0, 3)									3 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.32 (0.18, 0.47)	NA (NA, NA)	0.38 (0.25, 0.48)	0.4 (0.25, 0.47)	NA (NA, NA)	0.37 (0.28, 0.48)	NA (NA, NA)	0.42 (0.3, 0.49)									0.4 (0.28, 0.47)	NA (NA, NA)	0.43 (0.38, 0.48)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.12 (0.102, 0.171)	NA (NA, NA)	0.149 (0.101, 0.255)	0.177 (0.112, 0.763)	NA (NA, NA)	0.259 (0.128, 0.994)	0.19 (0.093, 0.287)	0.251 (0.098, 0.578)									0.152 (0.108, 0.684)	NA (NA, NA)	0.366 (0.107, 1.241)	NA (NA, NA)	0.11 (0.022, 0.269)	0.136 (0.136, 0.136)	0.486 (0.486, 0.486)	NA (NA, NA)
TP53+	TC1	count					33	33	33	33					33	33	33	33					33	33	33	33					33	33	33	33
TP53+	TC1	time					22 (16, 31)	22 (16, 31)	22 (16, 31)	22 (16, 31)					22 (16, 31)	22 (16, 31)	22 (16, 31)	22 (16, 31)					22 (16, 31)	22 (16, 31)	22 (16, 31)	22 (16, 31)					22 (16, 31)	22 (16, 31)	22 (16, 31)	22 (16, 31)
TP53+	TC1	n					7 (4, 15)	6 (3, 13)	2 (0, 4)	5 (2, 8)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	4 (2, 8)	3 (1, 7)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.37 (0.17, 0.48)	0.28 (0.17, 0.46)	0.39 (0.31, 0.45)	0.37 (0.22, 0.49)					NA (NA, NA)	0.45 (0.42, 0.49)	NA (NA, NA)	0.42 (0.33, 0.44)					0.45 (0.37, 0.48)	NA (NA, NA)	0.32 (0.2, 0.46)	0.32 (0.16, 0.46)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.133 (0.113, 0.264)	0.207 (0.112, 0.348)	0.227 (0.115, 1.672)	0.161 (0.117, 0.373)					0 (0, 0)	0.19 (0, 0.667)	1.315 (1.315, 1.315)	0.261 (0.081, 2.482)					0.123 (0, 3.38)	NA (NA, NA)	0.182 (0.11, 0.649)	0.213 (0.112, 0.621)					0.202 (0.038, 0.65)	NA (NA, NA)	NA (NA, NA)	0.118 (0.118, 0.118)
TP53+	TC2	count					38	38	38	38					38	38	38	38					38	38	38	38					38	38	38	38
TP53+	TC2	time					19 (15, 30)	19 (15, 30)	19 (15, 30)	19 (15, 30)					19 (15, 30)	19 (15, 30)	19 (15, 30)	19 (15, 30)					19 (15, 30)	19 (15, 30)	19 (15, 30)	19 (15, 30)					19 (15, 30)	19 (15, 30)	19 (15, 30)	19 (15, 30)
TP53+	TC2	n					5 (3, 10)	4 (2, 9)	3 (1, 5)	5 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	7 (4, 12)	3 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.32 (0.14, 0.47)	0.36 (0.18, 0.46)	0.37 (0.26, 0.46)	0.38 (0.2, 0.48)					NA (NA, NA)	0.44 (0.35, 0.48)	NA (NA, NA)	0.44 (0.41, 0.47)					0.44 (0.4, 0.48)	NA (NA, NA)	0.36 (0.17, 0.49)	0.38 (0.25, 0.48)					NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.175 (0.116, 0.343)	0.192 (0.11, 0.488)	0.199 (0.117, 0.459)	0.165 (0.112, 0.524)					NA (NA, NA)	0.193 (0.062, 0.962)	0 (0, 0)	0.267 (0.116, 0.555)					0.273 (0.114, 1.98)	0 (0, 0)	0.147 (0.103, 0.242)	0.197 (0.106, 0.553)					0.029 (0, 4.837)	0.311 (0.17, 0.452)	0.428 (0.428, 0.428)	0 (0, 0)
TP53+	TC3	count					49	49	49	49					49	49	49	49					49	49	49	49					49	49	49	49
TP53+	TC3	time					25 (17, 32)	25 (17, 32)	25 (17, 32)	25 (17, 32)					25 (17, 32)	25 (17, 32)	25 (17, 32)	25 (17, 32)					25 (17, 32)	25 (17, 32)	25 (17, 32)	25 (17, 32)					25 (17, 32)	25 (17, 32)	25 (17, 32)	25 (17, 32)
TP53+	TC3	n					7 (3, 15)	5 (2, 11)	2 (0, 4)	4 (2, 7)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					1 (0, 1)	0 (0, 0)	5 (2, 12)	4 (2, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.35 (0.17, 0.49)	0.37 (0.21, 0.48)	0.43 (0.28, 0.49)	0.32 (0.16, 0.47)					NA (NA, NA)	0.42 (0.3, 0.47)	NA (NA, NA)	0.41 (0.27, 0.47)					0.45 (0.38, 0.48)	NA (NA, NA)	0.36 (0.15, 0.47)	0.35 (0.24, 0.46)					0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.162 (0.107, 0.343)	0.167 (0.114, 0.389)	0.196 (0.091, 0.809)	0.194 (0.122, 0.464)					NA (NA, NA)	0.328 (0.121, 0.832)	0.185 (0.135, 0.234)	0.271 (0.142, 0.717)					0.138 (0, 0.464)	0.037 (0.007, 0.066)	0.162 (0.115, 0.341)	0.171 (0.104, 0.317)					0.177 (0, 2.244)	0.803 (0.42, 1.186)	0.505 (0.101, 0.909)	NA (NA, NA)
TP53+	TC4	count					14	14	14	14					14	14	14	14					14	14	14	14					14	14	14	14
TP53+	TC4	time					20 (18, 28)	20 (18, 28)	20 (18, 28)	20 (18, 28)					20 (18, 28)	20 (18, 28)	20 (18, 28)	20 (18, 28)					20 (18, 28)	20 (18, 28)	20 (18, 28)	20 (18, 28)					20 (18, 28)	20 (18, 28)	20 (18, 28)	20 (18, 28)
TP53+	TC4	n					6 (4, 12)	6 (3, 10)	0 (0, 4)	4 (3, 13)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	5 (2, 9)	5 (1, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.32 (0.11, 0.41)	0.39 (0.18, 0.47)	0.43 (0.41, 0.47)	0.34 (0.21, 0.48)					NA (NA, NA)	0.49 (0.46, 0.5)	NA (NA, NA)	0.5 (0.48, 0.5)					0.47 (0.4, 0.47)	NA (NA, NA)	0.34 (0.21, 0.43)	0.39 (0.22, 0.45)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.174 (0.122, 0.5)	0.153 (0.111, 0.251)	0.19 (0.18, 1.872)	0.159 (0.109, 0.274)					0 (0, 0)	0.24 (0.131, 3.667)	NA (NA, NA)	0.019 (0, 0.094)					0.185 (0.076, 0.364)	NA (NA, NA)	0.187 (0.128, 0.368)	0.201 (0.118, 1.126)					0.341 (0.158, 0.524)	NA (NA, NA)	0.198 (0.198, 0.198)	0 (0, 0)
TP53+	TC5	count					34	34	34	34					34	34	34	34					34	34	34	34					34	34	34	34
TP53+	TC5	time					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)
TP53+	TC5	n					5 (2, 8)	8 (4, 11)	2 (0, 4)	5 (2, 8)					0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	5 (1, 8)	5 (2, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.36 (0.19, 0.48)	0.3 (0.17, 0.49)	0.37 (0.26, 0.45)	0.31 (0.21, 0.47)					NA (NA, NA)	0.42 (0.37, 0.45)	NA (NA, NA)	0.41 (0.31, 0.48)					0.46 (0.41, 0.48)	NA (NA, NA)	0.36 (0.23, 0.48)	0.38 (0.25, 0.47)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.165 (0.102, 0.47)	0.157 (0.107, 0.235)	0.191 (0.107, 0.687)	0.17 (0.105, 0.367)					NA (NA, NA)	0.32 (0.084, 1.261)	0.311 (0.311, 0.311)	0.155 (0.047, 1.891)					0.145 (0.025, 0.341)	NA (NA, NA)	0.177 (0.122, 0.631)	0.156 (0.101, 0.376)					0.189 (0.189, 0.189)	0 (0, 0)	NA (NA, NA)	0.054 (0.011, 0.096)
TEfus+	TC1	count			20	20			20	20			20	20			20	20			20	20			20	20			20	20			20	20
TEfus+	TC1	time			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)			26 (19, 34)	26 (19, 34)
TEfus+	TC1	n			1 (1, 5)	4 (2, 5)			3 (1, 5)	4 (2, 9)			3 (0, 6)	1 (0, 2)			0 (0, 0)	1 (0, 2)			3 (1, 7)	1 (0, 2)			5 (2, 11)	4 (2, 7)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.38 (0.29, 0.47)	0.34 (0.2, 0.47)			0.39 (0.23, 0.47)	0.39 (0.29, 0.48)			0.36 (0.21, 0.49)	0.41 (0.33, 0.48)			NA (NA, NA)	0.43 (0.4, 0.47)			0.4 (0.27, 0.47)	0.38 (0.3, 0.48)			0.37 (0.17, 0.44)	0.34 (0.15, 0.48)			0.47 (0.45, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.311 (0.101, 0.963)	0.192 (0.13, 0.389)			0.184 (0.107, 0.62)	0.152 (0.113, 0.438)			0.163 (0.074, 0.351)	0.217 (0.124, 0.346)			NA (NA, NA)	0.183 (0.094, 3.785)			0.194 (0.116, 1.053)	0.171 (0.036, 0.972)			0.19 (0.107, 0.571)	0.165 (0.103, 0.562)			0.214 (0.027, 0.589)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			15	15			15	15			15	15			15	15			15	15			15	15			15	15			15	15
TEfus+	TC2	time			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)			25 (16, 31)	25 (16, 31)
TEfus+	TC2	n			1 (0, 3)	3 (1, 5)			2 (1, 4)	5 (2, 10)			2 (0, 4)	0 (0, 2)			0 (0, 0)	1 (0, 2)			3 (1, 5)	1 (0, 3)			7 (4, 12)	4 (1, 6)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.44 (0.34, 0.5)	0.28 (0.21, 0.39)			0.42 (0.31, 0.49)	0.36 (0.24, 0.46)			0.45 (0.28, 0.49)	0.37 (0.32, 0.46)			NA (NA, NA)	0.42 (0.37, 0.43)			0.43 (0.29, 0.49)	0.42 (0.36, 0.47)			0.34 (0.16, 0.48)	0.4 (0.19, 0.48)			0.46 (0.42, 0.46)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.19 (0.051, 0.227)	0.223 (0.17, 0.435)			0.141 (0.073, 0.207)	0.171 (0.109, 0.215)			0.128 (0.094, 0.716)	0.442 (0.142, 0.641)			NA (NA, NA)	0.147 (0.066, 0.372)			0.152 (0.097, 0.517)	0.232 (0.116, 0.453)			0.142 (0.108, 0.206)	0.171 (0.107, 0.401)			0.25 (0.07, 0.613)	NA (NA, NA)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	count			26	26			26	26			26	26			26	26			26	26			26	26			26	26			26	26
TEfus+	TC3	time			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)			24 (17, 34)	24 (17, 34)
TEfus+	TC3	n			2 (0, 3)	3 (0, 9)			1 (0, 3)	4 (1, 7)			4 (2, 7)	2 (0, 3)			0 (0, 0)	1 (0, 3)			1 (0, 3)	1 (0, 4)			6 (2, 10)	4 (2, 8)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.43 (0.33, 0.48)	0.41 (0.28, 0.49)			0.37 (0.26, 0.46)	0.38 (0.27, 0.48)			0.27 (0.16, 0.39)	0.35 (0.23, 0.46)			NA (NA, NA)	0.38 (0.33, 0.45)			0.4 (0.27, 0.44)	0.45 (0.27, 0.49)			0.31 (0.14, 0.39)	0.36 (0.23, 0.48)			0.44 (0.39, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.167 (0.06, 0.532)	0.167 (0.109, 0.426)			0.264 (0.124, 1.31)	0.161 (0.116, 0.391)			0.236 (0.149, 0.405)	0.201 (0.108, 1.306)			NA (NA, NA)	0.288 (0.106, 0.743)			0.332 (0.133, 2.483)	0.186 (0.08, 0.498)			0.17 (0.13, 0.312)	0.18 (0.123, 0.302)			0.28 (0.152, 1.505)	0.72 (0.72, 0.72)			0.106 (0.021, 0.305)	0.599 (0.599, 0.599)
TEfus+	TC4	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC4	time			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)			33 (33, 33)	33 (33, 33)
TEfus+	TC4	n			3 (3, 3)	5 (5, 5)			2 (2, 2)	6 (6, 6)			3 (3, 3)	0 (0, 0)			0 (0, 0)	0 (0, 0)			3 (3, 3)	1 (1, 1)			1 (1, 1)	4 (4, 4)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.45 (0.45, 0.45)	0.48 (0.48, 0.48)			0.43 (0.43, 0.43)	0.25 (0.25, 0.25)			0.48 (0.48, 0.48)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.42 (0.42, 0.42)	0.25 (0.25, 0.25)			0.37 (0.37, 0.37)	0.2 (0.2, 0.2)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.162 (0.162, 0.162)	0.084 (0.084, 0.084)			0.181 (0.181, 0.181)	0.161 (0.161, 0.161)			0.162 (0.162, 0.162)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.168 (0.168, 0.168)	1.072 (1.072, 1.072)			0.389 (0.389, 0.389)	0.258 (0.258, 0.258)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			15	15			15	15			15	15			15	15			15	15			15	15			15	15			15	15
TEfus+	TC5	time			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)			27 (16, 33)	27 (16, 33)
TEfus+	TC5	n			1 (0, 2)	4 (2, 7)			1 (0, 5)	5 (2, 13)			4 (1, 7)	1 (0, 5)			0 (0, 0)	0 (0, 2)			2 (1, 5)	2 (1, 3)			5 (2, 10)	4 (2, 7)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.4 (0.32, 0.47)	0.38 (0.22, 0.47)			0.41 (0.3, 0.48)	0.34 (0.17, 0.49)			0.39 (0.18, 0.45)	0.45 (0.4, 0.47)			NA (NA, NA)	0.46 (0.41, 0.48)			0.41 (0.25, 0.49)	0.42 (0.27, 0.47)			0.4 (0.16, 0.45)	0.32 (0.12, 0.47)			0.43 (0.43, 0.43)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.289 (0.149, 1.046)	0.162 (0.091, 1.005)			0.192 (0.111, 0.249)	0.154 (0.1, 0.38)			0.158 (0.116, 0.371)	0.138 (0.043, 0.401)			NA (NA, NA)	0.143 (0.111, 0.988)			0.206 (0.092, 0.664)	0.213 (0.06, 1.747)			0.21 (0.116, 0.616)	0.178 (0.102, 0.532)			0.34 (0.066, 1.087)	NA (NA, NA)			0.131 (0.131, 0.131)	NA (NA, NA)
PI3K+	TC1	count		29		29		29		29		29		29		29		29		29		29		29		29		29		29		29		29
PI3K+	TC1	time		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)
PI3K+	TC1	n		7 (3, 18)		3 (1, 6)		6 (2, 10)		4 (2, 9)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 3)		1 (0, 2)		1 (0, 3)		0 (0, 0)		3 (1, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.34 (0.14, 0.46)		0.4 (0.27, 0.48)		0.32 (0.18, 0.45)		0.35 (0.21, 0.47)		NA (NA, NA)		0.43 (0.36, 0.48)		0.43 (0.4, 0.49)		0.39 (0.33, 0.46)		0.44 (0.36, 0.48)		0.42 (0.33, 0.44)		NA (NA, NA)		0.34 (0.18, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.136 (0.105, 0.274)		0.167 (0.105, 0.32)		0.168 (0.115, 0.506)		0.169 (0.107, 0.278)		0.323 (0.311, 0.335)		0.234 (0.078, 0.566)		0.188 (0.049, 0.269)		0.256 (0.087, 1.031)		0.224 (0.14, 0.902)		0.21 (0.039, 0.632)		0.057 (0.011, 0.103)		0.177 (0.119, 0.635)		NA (NA, NA)		0.133 (0.133, 0.133)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		28		28		28		28		28		28		28		28		28		28		28		28		28		28		28		28
PI3K+	TC2	time		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)		24 (18, 35)
PI3K+	TC2	n		6 (3, 11)		4 (1, 8)		4 (1, 11)		6 (2, 11)		0 (0, 0)		1 (0, 2)		1 (0, 3)		1 (0, 3)		1 (0, 3)		2 (1, 3)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 1)		0 (0, 0)
PI3K+	TC2	post_p		0.35 (0.16, 0.49)		0.38 (0.24, 0.46)		0.29 (0.16, 0.46)		0.4 (0.26, 0.48)		NA (NA, NA)		0.42 (0.38, 0.49)		0.43 (0.37, 0.47)		0.44 (0.36, 0.47)		0.44 (0.33, 0.47)		0.41 (0.36, 0.48)		NA (NA, NA)		0.35 (0.2, 0.47)		NA (NA, NA)		NA (NA, NA)		0.43 (0.43, 0.43)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.169 (0.108, 0.309)		0.165 (0.113, 0.31)		0.198 (0.127, 0.477)		0.141 (0.104, 0.295)		0 (0, 0)		0.127 (0.072, 0.501)		0.162 (0.082, 0.509)		0.245 (0.125, 0.538)		0.188 (0.087, 0.624)		0.226 (0.09, 0.641)		0.063 (0.013, 0.113)		0.199 (0.107, 0.675)		NA (NA, NA)		0.073 (0.073, 0.073)		0.172 (0.072, 0.404)		NA (NA, NA)
PI3K+	TC3	count		32		32		32		32		32		32		32		32		32		32		32		32		32		32		32		32
PI3K+	TC3	time		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)		24 (17, 32)
PI3K+	TC3	n		6 (2, 11)		3 (1, 8)		5 (3, 11)		4 (2, 7)		0 (0, 0)		2 (0, 4)		1 (0, 3)		1 (0, 3)		0 (0, 2)		1 (0, 3)		0 (0, 1)		4 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.36 (0.23, 0.48)		0.38 (0.27, 0.48)		0.34 (0.22, 0.47)		0.37 (0.18, 0.48)		NA (NA, NA)		0.36 (0.23, 0.4)		0.44 (0.32, 0.48)		0.39 (0.35, 0.47)		0.46 (0.36, 0.48)		0.42 (0.35, 0.46)		NA (NA, NA)		0.34 (0.21, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.44 (0.44, 0.44)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.143 (0.109, 0.351)		0.192 (0.097, 0.995)		0.167 (0.113, 0.31)		0.157 (0.111, 0.504)		0.078 (0.078, 0.078)		0.213 (0.15, 0.642)		0.396 (0.131, 3.066)		0.168 (0.09, 0.641)		0.176 (0, 0.945)		0.235 (0.007, 1.667)		0.037 (0, 0.237)		0.173 (0.111, 0.32)		0.091 (0.091, 0.091)		0.216 (0.216, 0.216)		1.281 (1.281, 1.281)		3.134 (3.134, 3.134)
PI3K+	TC4	count		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4
PI3K+	TC4	time		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)		26 (21, 34)
PI3K+	TC4	n		10 (6, 15)		3 (2, 5)		10 (4, 14)		6 (4, 7)		0 (0, 0)		0 (0, 2)		0 (0, 1)		1 (0, 2)		1 (0, 2)		1 (0, 2)		0 (0, 0)		6 (5, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.43 (0.36, 0.48)		0.36 (0.2, 0.48)		0.32 (0.19, 0.46)		0.29 (0.19, 0.39)		NA (NA, NA)		0.4 (0.4, 0.4)		0.5 (0.5, 0.5)		0.46 (0.46, 0.46)		0.36 (0.35, 0.45)		0.45 (0.43, 0.47)		NA (NA, NA)		0.4 (0.32, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.148 (0.129, 0.167)		0.159 (0.107, 0.265)		0.151 (0.115, 0.322)		0.178 (0.12, 0.473)		NA (NA, NA)		0.111 (0.111, 0.111)		0.227 (0.227, 0.227)		0.026 (0.005, 0.117)		0.445 (0.355, 0.839)		1.273 (0.375, 2.171)		NA (NA, NA)		0.189 (0.143, 0.2)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		43		43		43		43		43		43		43		43		43		43		43		43		43		43		43		43
PI3K+	TC5	time		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)		17 (9, 27)
PI3K+	TC5	n		7 (5, 15)		4 (1, 6)		6 (4, 10)		4 (2, 7)		0 (0, 0)		0 (0, 3)		0 (0, 2)		0 (0, 3)		0 (0, 2)		1 (0, 3)		0 (0, 0)		5 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.36 (0.18, 0.46)		0.44 (0.22, 0.49)		0.36 (0.12, 0.48)		0.37 (0.12, 0.46)		NA (NA, NA)		0.44 (0.36, 0.49)		0.44 (0.39, 0.47)		0.42 (0.29, 0.48)		0.46 (0.38, 0.46)		0.44 (0.32, 0.47)		NA (NA, NA)		0.39 (0.17, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.141 (0.096, 0.248)		0.144 (0.079, 0.475)		0.159 (0.107, 0.288)		0.169 (0.098, 0.34)		NA (NA, NA)		0.257 (0.068, 1.202)		0.204 (0.049, 0.607)		0.174 (0.099, 0.485)		0.175 (0, 0.744)		0.205 (0.039, 0.681)		0.216 (0.216, 0.216)		0.156 (0.088, 0.403)		NA (NA, NA)		0.194 (0.194, 0.194)		0.32 (0.32, 0.32)		NA (NA, NA)